Table 2. Extensive study for the association of SNPs in the vicinity of TOMM40-APOE region.
SNP ID | Position (bp)a | Gene | Alleleb | Genotype countse | minor allele frequency | OR (95% CI) | Allelic P | ||
Cases | Controls | Cases | Controls | ||||||
rs1871046 | 50043777 | PVRL2 | G/A | 19/204/374 | 45/434/796 | 0.203 | 0.205 | 0.983(0.83–1.17) | 0.843 |
rs12978931 | 50055540 | PVRL2 | G/A | 151/283/158 | 271/628/376 | 0.494 | 0.459 | 1.152 (1.00–1.32) | 0.0445 |
rs519825 | 50058619 | PVRL2 | G/A | 14/143/440 | 18/258/999 | 0.143 | 0.115 | 1.283(1.05–1.57) | 0.01577 |
rs419010 | 50060160 | PVRL2 | A/G | 261/253/82 | 489/607/179 | 0.350 | 0.378 | 1.131(0.98–1.31) | 0.091 |
rs4803766 | 50063008 | PVRL2 | A/G | 72/279/246 | 159/600/514 | 0.354 | 0.361 | 0.972(0.84–1.12) | 0.708 |
rs11879589 | 50065116 | PVRL2 | A/G | 0/21/576 | 0/27/1248 | 0.018 | 0.011 | 1.673(0.94–2.97) | 0.07601 |
rs395908 | 50065405 | PVRL2 | T/C | 463/121/13 | 1026/239/10 | 0.123 | 0.102 | 0.805(0.65–1.00) | 0.048 |
rs519113 | 50068124 | PVRL2 | C/G | 8/109/480 | 23/246/1006 | 0.105 | 0.115 | 0.904(0.72–1.13) | 0.3734 |
rs6857 | 50084094 | PVRL2 | A/G | 0/55/542 | 0/130/1145 | 0.046 | 0.051 | 0.899(0.65–1.24) | 0.518 |
rs10119 | 50098513 | TOMM40 | T/C | 593/4/0 | 1267/8/0 | 0.003 | 0.003 | 0.936(0.28–3.12) | 0.914 |
rs449647 | 50100404 | APOE | A/T | 21/203/368 | 53/421/786 | 0.207 | 0.209 | 1.013(0.85–1.20) | 0.767 |
rs405509 | 50100676 | APOE | C/A | 63/277/257 | 112/545/618 | 0.338 | 0.302 | 1.180(1.02–1.37) | 0.027 |
rs440446 | 50101007 | APOE | G/C | 23/184/380 | 49/433/789 | 0.196 | 0.209 | 1.083(0.912–1.289) | 0.509 |
rs769448 | 50101419 | APOE | T/C | 0/39/554 | 0/91/1183 | 0.033 | 0.036 | 1.089(0.744–1.595) | 0.660 |
rs769449 | 50101842 | APOE | A/G | 4/109/484 | 6/213/1051 | 0.098 | 0.089 | 0.895(0.707–1.131) | 0.620 |
rs7412 | 50103919 | APOE | T/C | 9/112/470 | 21/273/970 | 0.110 | 0.125 | 1.152(0.927–1.431) | 0.405 |
rs429358 | 50103781 | APOE | C/T | 7/90/491 | 12/230/1033 | 0.088 | 0.10 | 0.877(0.69–1.11) | 0.2821 |
rs4420638 | 50114786 | APOC1 | G/A | 3/104/489 | 8/266/1011 | 0.092 | 0.107 | 0.851(0.67–1.07) | 0.176 |
Genomic positions are according to NCBI build 36;
Minor allele/major allele;
The genotype counts are presented as homozygote/heterozygote/wildtype;