Table 5. Conditional analysis of the PVRL2-TOMM40-APOE locus in a replication cohort.

SNP ID	Position (bp)a	Gene	Alleleb	Conditional on PVRL2 rs519825c		Conditional on TOMM40 rs2075650c		Conditional on APOE rs405509c
				P	OR	P	OR	P	OR
rs12978931	50055540	PVRL2	G/A	0.80	0.97(0.77–1.21)	0.14	0.77(0.62–0.95)	0.50	0.88(0.63–1.25)
rs519825	50058619	PVRL2	G/A	-	-	0.77	1.04(0.77–1.40)	6.95E-04
rs395908	50065405	PVRL2	T/C	0.68	1.07(0.77–1.47)	0.39	1.12(0.84–1.23)	0.98	0.99(0.7–1.4)
rs2075650	50087459	TOMM40	G/A	0.0000156	2.41(1.60–3.64)	-	-	7.84E-06	2.60(1.69–4.0)
rs405509	50100676	APOE	C/A	0.15	1.21(0.93–1.58)	0.79	0.97(0.78–1.20)	-	-

^aGenomic positions are according to NCBI build 36;

^bMinor allele/major allele;

^cThe results of association testing of the PVRL2-TOMM40-APOE locus when the allelic dosage of rs519825, rs2075650 or rs405509 was included in the regression model.