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. 2014 Jun 12;10(6):e1004178. doi: 10.1371/journal.ppat.1004178

Table 1. RNA-binding proteins and translation factors that increase BLA resistance.

Locus number Description Number locations Fold per CDS
RNA binding proteins
Tb927.4.400 DRBD7 3 11.5
Tb927.10.11270 RBP23 7 23.6
Tb927.7.880 RBP25 5 8.7
Tb927.10.13720 RBP29 8 10.1
Tb927.6.4440 RBP42 15 10.6
Tb927.9.8740 DRBD3 (PTB1) 2 14.6
Tb927.11.14100 DRBD4 (PTB2) 10 11.1
Tb927.3.3960 DRBD6A 7 42.8
Tb927.3.790 ZC3H6 10 4.8
Tb927.5.810 ZC3H11 10 24.0
Tb927.7.2660 ZC3H20 9 122.1
Tb927.7.2670 ZC3H21 7 65.1
Tb927.8.4020 ZC3H24 6 26.2
Tb927.8.4070 ZC3H25 7 26.2
Tb927.8.4120 ZC3H26 7 26.2
Tb927.9.9450 ZC3H28 24 25.3
Tb927.10.5150 ZC3H31 4 4.2
Tb927.10.12330 ZC3H34 7 20.9
Tb927.10.12760 ZC3H36 7 50.0
Tb927.10.12780 ZC3H37 10 64.7
Tb927.10.12800 ZC3H38 15 48.6
Tb927.10.14930 ZC3H39 6 6.8
Tb927.10.14950 ZC3H40 16 15.4
Tb927.2.4710 TRRM1 5 6.0
Tb927.9.9290 PABP1 11 58.4
Tb927.9.10770 PABP2 10 45.7
Tb927.11.6240 2 weak RBDs 10 14.1
Tb927.3.1910 histone RBD 4 6.2
Other known factor
Tb927.8.4540 PBP1 15 91.6
Translation factors
Tb927.7.1710 DOM34 2 14.3
Tb927.3.2900 EF-2 alpha 6 6.7
Tb927.11.11770 eIF4E3 5 88.6
Tb927.6.1870 eIF4E4 18 23.3
Tb927.9.5460 eIF4G2 10 5.1
Tb927.11.10560 eIF4G4 8 38.5
Tb927.8.4500 eIF4G5 9 26.5
Tb927.11.5840 SUI1 homologue 2 20.6
Tb927.11.12670 TYW3 homologue 4 14.2

The number of locations is the number of positions at which a fusion protein caused at least a 3-fold increase in reads per million in the BLA6x or BLA10x condition. ‘Fold per CDS’ is the average increase for the whole CDS, including experiment A (BLA6x, 30 µg/ml) and experiment B (BLA10x, 50 µg/ml). Other proteins that are thought to increase stability and/or translation were positive in only one experiment or with only one fragment. These included the pumilio domain protein PUF9 [12], the ALBA proteins [13], the small CCCH protein ZFP3 [9], [58], [59] the 33 kDa subunit homolog of the cycle sequence binding protein (CSBP, [60] and RBP33 [34].