Table 1.
Right and left ventricular parameter before and after fingolimod application
| Diagnosed PAH | Pre-FTY | Post-FTY 1 month | 3 month follow up | 9 month follow up | |
|---|---|---|---|---|---|
| NYHA |
III |
II |
II |
II |
II |
| HR [bpm] |
80 |
77 |
65 |
60 |
68 |
| BP [mmHg] |
120/88 |
130/80 |
110/90 |
122/85 |
125/85 |
| RVESP [mmHg] |
90 |
70 |
65 |
n.d. |
55 |
| TAPSE [mm] |
13 |
21 |
n.d. |
n.d. |
20 |
| Right ventricle hypertrophy |
mild |
mild |
mild |
n.d. |
mild |
| LV EF |
45% |
60% |
60% |
n.d. |
60% |
| NT-proBNP [pmol/L] |
207 |
17 |
16 |
15 |
11 |
| pH (cap.) |
7.46 |
7.54 |
7.52 |
7.47 |
7.43 |
| PO2 (cap.) [kPa] |
12.3 |
10.1 |
11.7 |
10.4 |
10.4 |
| PCO2 (cap.) [kPa] |
3.9 |
4.6 |
3.5 |
4.6 |
4,72 |
| Respiratory resistance |
Normal |
Normal |
Normal |
Normal |
Normal |
| Obstructive ventilation |
Normal |
Normal |
Normal |
Normal |
Normal |
| Restrictive ventilation |
Normal |
Normal |
Normal |
Normal |
Normal |
| Diffusion respiration | TLCO SB 49% | TLCO SB 51% | TLCO SB 53% | TLCO SB 50% | TLCO SB 49% |
FTY, Fingolimod; n.d., not done. Reference values: RVESP: 15–30 mmHg; TAPSE: < 20 mm; LV-EF, left ventricular ejection fraction: 50–70%; NT-proBNP: ≤ 17 pmol/L, pH (capillary): 7.35-7.45; PO2 (capillary), partial pressure of oxygen: 11.1-14.4 kPa; PCO2 (capillary), partial pressure of carbon dioxide: 4.27-6.4 kPa; TLCO SB, transfer coefficient of lung for carbon monoxide: > 60%.