Table 2.
Parameter of systemic circulation during passive orthostatic tilt test before and after fingolimod application
| |
Pre-FTY baseline |
2 h post-FTY |
4 h post-FTY |
6 h post-FTY |
3 month follow-up |
9 month follow-up |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| → | ↑ | → | → | ↑ | → | → | ↑ | → | → | ↑ | → | → | ↑ | → | → | ↑ | → | |
| HR [bpm] |
74 |
84 |
80 |
70 |
73 |
66 |
61 |
64 |
59 |
74 |
76 |
74 |
65 |
70 |
65 |
60 |
64 |
62 |
| Psyst [mmHg] |
143 |
130 |
156 |
123 |
108 |
129 |
134 |
114 |
133 |
127 |
118 |
134 |
156 |
126 |
131 |
149 |
127 |
136 |
| Pdiast [mmHg] |
85 |
82 |
92 |
65 |
65 |
72 |
71 |
67 |
72 |
68 |
70 |
75 |
74 |
72 |
71 |
77 |
75 |
77 |
| TPR [mmHg *s/ml] |
1.43 |
1.55 |
1.5 |
0.68 |
0.76 |
0.83 |
0.92 |
0.86 |
0.9 |
0.69 |
0.88 |
0.85 |
0.81 |
1.06 |
0.93 |
1.1 |
1.41 |
1.23 |
| CO [lpm] |
3.9 |
3.5 |
4.3 |
8.4 |
5.9 |
6.9 |
6.7 |
6.3 |
6.5 |
7.9 |
6.1 |
7.1 |
7.4 |
4.9 |
6.2 |
5.9 |
4.5 |
5.1 |
| SV |ml] |
50 |
43 |
54 |
119 |
83 |
67 |
106 |
97 |
116 |
109 |
78 |
103 |
116 |
72 |
96 |
102 |
70 |
83 |
| E/I | 1.16 | 1.13 | 1.14 | 1.16 | 1.06 | 1.09 | ||||||||||||
FTY, Fingolimod. → lying position; ↑ tilted position. Reference values: HR: 60–100 bpm; Psyst, systolic blood pressure: 100–140 mmHg; Pdiast, diastolic blood pressure: 60–90 mmHg; TPR, total peripheral resistance: 0.6-1.3 mmHg*s/ml; CO, cardiac output: 4–8 lpm; SV, stroke volume: 55–100 ml; E/I: > 1.11.