Table 1.
Levels of Cytokines and Chemokines in Lung Homogenates of Pseudomonas aeruginosa–Infected Mice Treated for 12 Days With Vehicle or PTX3
| Variable | Level, pg/mL, Median (IQR) |
Pa |
||||
|---|---|---|---|---|---|---|
| Non-CF | CF | CF-PTX3 | CF vs Non-CF | CF vs CF-PTX3 | Non-CF vs CF-PTX3 | |
| IL-1β | 268.6 (114) | 652.7 (589) | 298.1 (351) | .014 | .068 | .309 |
| IL-17 | 86.8 (44) | 135.3 (67) | 93.3 (54) | .012 | .025 | .554 |
| CCL2/MCP-1 | 40.5 (44) | 314.2 (696) | 102.4 (210) | .014 | .102 | .140 |
| CXCL1/KC | 5.7 (5) | 12.1 (13) | 10.3 (4) | .012 | .171 | .038 |
| CXCL2/MIP-2 | 13.2 (14) | 41 (51) | 9.9 (12) | .021 | .021 | .972 |
| TGF-β1 | 52 (23) | 49.5 (18) | 44.4 (23) | .732 | .447 | .921 |
| INF-γ | ND | ND | ND | |||
| IL-13 | ND | ND | ND | |||
| IL-6 | 112.7 (136) | 122.8 (119) | 143.5 (82) | .447 | .909 | .554 |
| IL-4 | ND | ND | ND | |||
| IL-10 | ND | ND | ND | |||
Abbreviations: CF, mice with cystic fibrosis that received vehicle; CF-PTX3, mice with cystic fibrosis that received PTX3; IL-1β, interleukin 1β; IL-4, interleukin 4; IL-6, interleukin 6; IL-10, interleukin 10; IL-13, interleukin 13; IL-17, interleukin 17; INF-γ, interferon γ; IQR, interquartile range; ND, not detectable; non-CF, mice without cystic fibrosis that received vehicle; TGF-β1, transforming growth factor β1.
a By the nonparametric Mann–Whitney U test.