Fig 2.

SCI-N and SCI-P groups compared with controls: averaged ROI volumes were extracted for the supra-threshold clusters identified from whole brain contrasts (p < 0.001 uncorrected) in Table 2. Changes were found in (i) the sensorimotor tract and (ii) visual processing areas. Areas associated with the corticospinal tract showed reduced volume (white matter). Compared with controls, the SCI-P group showed reduced white matter (WM) volume in the pyramids and also in two further regions: deep to S2 (A), and in the area of the posterior corona radiata (B). The SCI-N group showed white matter changes also in the pyramids but not in any other locations (C) (ii). Mixed visual stream changes were found (both grey matter and white matter). The SCI-P group showed a decrease of white matter medially in the cuneus (D). The SCI-N subgroup showed increased grey matter in the adjacent lateral cuneus extending into the precuneus (E). The anatomical relationship between visual cortex clusters is shown in (F). When tissue volumes were extracted for each region and compared across the three groups, variation between groups was revealed (G). Note that error bars indicate 95% confidence intervals for the mean and are based on raw extracted tissue volumes. Asterisks represent t-tests that showed significant group differences of averaged extracted supra-threshold cluster volumes (p < 0.05). All images are displayed on an averaged template based on all study participants, thresholded at p < 0.001 uncorrected.