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. 2011 Apr 7;4(4):603–629. doi: 10.3390/ph4040603

Table 2.

Acute and chronic effects of 5-HT3 receptors antagonists on the number of DA cell/track. 5-HT3 receptor antagonists had either no effect (0) either an increase (+) or a decrease (−) on the number of cell/track.

Cell per track
5-HT3 receptor antagonist Duration Dose A9 (SNc) A10 (VTA)
Dolasetron [117] Acute treatment 500 µg/kg, i.v. 0 0
Zatosetron [116] 0.1 mg/kg, i.v. 0 +
1 mg/kg, i.v. 0 +
Zatosetron [147] 10 mg/kg, i.v. 0 0
0.01 mg/kg, i.p. 0 0
0.1 mg/kg, i.p. 0
1 mg/kg, i.p. 0 0
10 mg/kg, i.p. 0 0
Itasetron [118] 15 µg/kg, s.c. 0 +
Dolasetron [117] Chronic treatment (21 days) 5 mg/kg/day, i.p.
Granisetron [137] 5 mg/kg/day, i.p. 0 0
10 mg/kg/day, i.p. 0 0
Itasetron [118] 30 µg/kg/day, s.c. 0
Zatosetron [116] 0.1 mg/kg/day, i.p.
1 mg/kg/day, i.p. 0 +
10 mg/kg/day, i.p. 0
Zatosetron [147] 0.01 mg/kg, i.p. 0 0
0.1 mg/kg, i.p. 0
1 mg/kg, i.p. 0 0
10 mg/kg, i.p. 0 0