Table 2.
Acute and chronic effects of 5-HT3 receptors antagonists on the number of DA cell/track. 5-HT3 receptor antagonists had either no effect (0) either an increase (+) or a decrease (−) on the number of cell/track.
Cell per track | ||||
---|---|---|---|---|
5-HT3 receptor antagonist | Duration | Dose | A9 (SNc) | A10 (VTA) |
Dolasetron [117] | Acute treatment | 500 µg/kg, i.v. | 0 | 0 |
Zatosetron [116] | 0.1 mg/kg, i.v. | 0 | + | |
1 mg/kg, i.v. | 0 | + | ||
Zatosetron [147] | 10 mg/kg, i.v. | 0 | 0 | |
0.01 mg/kg, i.p. | 0 | 0 | ||
0.1 mg/kg, i.p. | 0 | − | ||
1 mg/kg, i.p. | 0 | 0 | ||
10 mg/kg, i.p. | 0 | 0 | ||
Itasetron [118] | 15 µg/kg, s.c. | 0 | + | |
Dolasetron [117] | Chronic treatment (21 days) | 5 mg/kg/day, i.p. | − | − |
Granisetron [137] | 5 mg/kg/day, i.p. | 0 | 0 | |
10 mg/kg/day, i.p. | 0 | 0 | ||
Itasetron [118] | 30 µg/kg/day, s.c. | 0 | − | |
Zatosetron [116] | 0.1 mg/kg/day, i.p. | − | − | |
1 mg/kg/day, i.p. | 0 | + | ||
10 mg/kg/day, i.p. | 0 | − | ||
Zatosetron [147] | 0.01 mg/kg, i.p. | 0 | 0 | |
0.1 mg/kg, i.p. | 0 | − | ||
1 mg/kg, i.p. | 0 | 0 | ||
10 mg/kg, i.p. | 0 | 0 |