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. 2014 Jun 13;4:5285. doi: 10.1038/srep05285

Figure 6. Impact of statins on cellular and C. elegans metabolism.

Figure 6

(A–G) Effect of 24 hours treatment with atorvastatin, fluvastatin and simvastatin in Hepa1.6 on ATP level (A), redox potential (B), Δψm (C), DNA content (D), extra-cellular acidification rate (ECAR) (E), basal oxygen consumption rate (OCR) (F) and uncoupled OCR (G). (H) Acute effect of statins on OCR in Hepa1.6. Measurement was performed 3 minutes after addition of the compounds. (I) Fluvastatin does not impair the development of C. elegans N2 worms at 10, 20 and 50 μM. Pictures were taken at day 3 of adulthood. (J–K) Effect of fluvastatin on basal OCR (J) and uncoupled OCR (K) at day 1 of adulthood. (L) Lifespan in N2 worms after treatment with fluvastatin at 20 and 50 μM. Results are expressed as ratio over DMSO control and as mean ± SEM. Grey zone represents the DMSO 95% confidence interval. Significance was tested using a two-way ANOVA test, with Bonferroni correction for multiple comparison. * P<0.05, ** P<0.01 and *** P<0.001.