Skip to main content
. 2014 Apr 29;123(24):3750–3759. doi: 10.1182/blood-2014-01-552174

Figure 2.

Figure 2

IL-7 and IL-15 better preserve CD8+ CD45RA+ CCR7+ cells in ex vivo expanded CAR-T cells than IL-2. (A) T-cell memory phenotypic analysis based on CD45RA and CCR7 expression by CAR-T cells exposed to either IL-2 or IL-7 and IL-15 (n = 4). (B) Representative flow cytometry analysis. (C) Numeric expansion of CAR+CD8+CD45RA+CCR7+ cells in culture conditions with either IL-2 or IL-7 and IL-15 (n = 3). (D) Expression of the CD45RO and CD45RA isoforms by CAR-T cells. Data shown are representative of 3 independent experiments. (E) Expression of CD27, CD28, CD62L, and CD127 in CAR-T cells. Data shown are representative of 3 independent experiments.