Table 2.
Factors independently associated with 60-day mortality between initially and secondarily adequate antibiotic therapy groups
| Multivariate analysis (n = 898) | sHR (95% CI) | P- value |
|---|---|---|
|
Inadequate antibiotic therapy (reference) |
0.63 (0.42 to 0.94) |
0.02 |
|
Initial adequate antibiotic therapy | ||
|
Secondary adequate antibiotic therapy |
0.69 (0.37 to 1.27) |
0.23 |
| SAPSII per 10 points |
1.65 (1.53 to 1.77) |
<.0001 |
| Female gender |
0.70 (0.52 to 0.94) |
0.02 |
| At least one co-morbidity |
1.49 (1.13 to 1.97) |
0.005 |
| Adequate antibiotic therapy on day 2 versus day 1 |
1.33 (0.92 to 1.93) |
0.13 |
| Adequate antibiotic therapy on day 3 versus day 1 |
1.29 (0.76 to 2.20) |
0.35 |
| Corticosteroids | 0.98 (0.72 to 1.32) | 0.87 |
95% CI, 95% confidence interval; SAPSII, Simplified Acute Physiology Score version II; sHR, subdistribution hazard ratio.