Table 4.
Factors associated with 60-day mortality in the groups given monotherapy or dual therapy
| Multivariate analysis | sHR | 95% CI | P- value |
|---|---|---|---|
| Dual therapy versus monotherapy |
1.14 |
0.86 to 1.50 |
0.37 |
| SAPSII (per 10 points) |
1.66 |
1.54 to 1.79 |
<.0001 |
| Female gender |
0.72 |
0.53 to 0.96 |
0.03 |
| ≥One co-morbidity |
1.43 |
1.07 to 1.91 |
0.01 |
| Antibiotic therapy on Day 2 versus Day 1 |
1.38 |
0.98 to 1.93 |
0.07 |
| Antibiotic therapy on Day 3 versus Day 1 |
1.28 |
0.75 to 2.19 |
0.36 |
| Steroids |
0.97 |
0.71 to 1.32 |
0.83 |
|
Multivariate sensitivity analysis* |
sHR |
(95% CI) |
P
-value |
| Restricted to Streptococcus pneumoniae infection |
1.42 |
0.73 to 2.77 |
0.31 |
| Restricted to documented infection |
1.29 |
0.89 to 1.89 |
0.18 |
| Restricted to patients with septic shock | 1.11 | 0.75 to 1.64 | 0.59 |
*Adjusted on SAPSII, female gender, at least one co-morbidity, day of antibiotic therapy initiation and use of steroids.