Table 2.
Association between DNA repair genotypes and colon cancer risk by race
| African Americans | Whites | |||||
|---|---|---|---|---|---|---|
| Cases/controls | ORa | 95% CI | Cases/controls | ORa | 95%CI | |
| XPD/ERCC2 | ||||||
| DD | 170 / 258 | 1.0 | Ref | 136 / 230 | 1.0 | Ref |
| DN | 45 / 60 | 1.1 | (0.7, 1.8) | 119 / 238 | 0.8 | (0.6, 1.1) |
| NN | 5 / 3 | 2.7 | (0.6, 11.9) | 40 / 57 | 1.2 | (0.7, 1.8) |
| DN+NN | 50 / 63 | 1.2 | (0.8, 1.9) | 159 / 295 | 0.9 | (0.7, 1.2) |
| XPD/ERCC2 | ||||||
| KK | 128 / 186 | 1.0 | Ref | 114 / 209 | 1.0 | Ref |
| KQ | 83 / 115 | 1.1 | (0.8, 1.6) | 136 / 251 | 1.0 | (0.7, 1.3) |
| 13 / 19 | 1.0 | (0.5, 2.1) | 49 / 65 | 1.3 | (0.9, 2.1) | |
| KQ+QQ | 96 / 134 | 1.1 | (0.8, 1.5) | 185 / 316 | 1.1 | (0.8, 1.4) |
| XPF/ERCC4 | ||||||
| RR | 217 / 307 | 1.0 | Ref | 251 / 455 | 1.0 | Ref |
| RQ | 8 / 16 | 0.8 | (0.3, 1.8) | 52 / 74 | 1.3 | (0.9, 1.9) |
| 1 / 0 | -- | -- | 1 / 7 | 0.3 | (0.03, 2.1) | |
| RQ+QQ | 9 / 16 | 0.8 | (0.4, 1.9) | 53 / 81 | 1.2 | (0.8, 1.7) |
| XPG/ERCC5 | ||||||
| DD | 65 / 100 | 1.0 | Ref | 183 / 335 | 1.0 | Ref |
| DH | 120 / 151 | 1.2 | (0.8, 1.8) | 100 / 170 | 1.1 | (0.8, 1.5) |
| HH | 39 / 66 | 0.9 | (0.5, 1.5) | 15 / 27 | 1.1 | (0.5, 2.0) |
| DH+HH | 159 / 217 | 1.1 | (0.8, 1.6) | 113 / 197 | 1.1 | (0.8, 1.5) |
| XPC A499V | ||||||
| AA | 175 / 276 | 1.0 | Ref | 177 / 293 | 1.0 | Ref |
| AV | 51 / 47 | 1.7 | (1.1, 2.6) | 104 / 207 | 0.8 | (0.6, 1.1) |
| VV | 2 / 0 | -- | -- | 22 / 35 | 1.0 | (0.6, 1.8) |
| AV+VV | 53 / 47 | 1.7 | (1.1, 2.7) | 126 / 242 | 0.9 | (0.7, 1.2) |
| XPC K939Q | ||||||
| KK | 126 / 149 | 1.0 | Ref | 103 / 191 | 1.0 | Ref |
| KQ | 91 / 142 | 0.8 | (0.6, 1.2) | 148 / 252 | 1.1 | (0.8, 1.5) |
| 9 / 31 | 0.3 | (0.2, 0.8) | 52 / 89 | 1.1 | (0.7, 1.6) | |
| KQ+QQ | 100 / 173 | 0.7 | (0.5, 1.0) | 200 / 341 | 1.1 | (0.8, 1.5) |
| RAD23B A249V | ||||||
| AA | 203 / 292 | 1.0 | Ref | 195 / 327 | 1.0 | Ref |
| AV | 20 / 28 | 0.9 | (0.5, 1.7) | 99 / 182 | 0.9 | (0.7, 1.2) |
| VV | -- | -- | -- | 3 / 8 | 0.7 | (0.2, 2.5) |
| AV+VV | 20 / 28 | 0.9 | (0.5, 1.7) | 102 / 190 | 0.9 | (0.7, 1.2) |
| # ‘At-Risk’ Allelesb | ||||||
| 0 or 1 | 49 / 69 | 1.0 | Ref | 25 / 49 | 1.0 | Ref |
| 2 or 3 | 105 / 164 | 0.9 | (0.6, 1.4) | 93 / 181 | 0.9 | (0.5, 1.6) |
| 4 or 5 | 44 / 61 | 1.0 | (0.6, 1.8) | 111 / 185 | 1.1 | (0.6, 1.8) |
| 6 or more | 6 / 6 | 1.1 | (0.3, 3.9) | 42 / 69 | 1.1 | (0.6, 2.0) |
a
Adjusted for age, gender and offsets
b
The ‘at-risk’ allele was defined as follows: XPD D312N: N allele; XPD K751Q: Q allele; XPF R415Q: Q allele; XPD D1104H: H allele; XPC A499V: V allele; XPCK939Q: K allele; RAD23B A249V: V allele. The XPC 939 less common allele was associated with reduced risk in this population, thus the more common allele was considered the ‘at-risk’ allele.