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. 2014 May 27;110(12):2975–2984. doi: 10.1038/bjc.2014.258

Table 2. Prognostic capacity of gene sets with similar temporal expression profiles in three ovarian cancer data sets (log rank P-values).

Data set Bild et al (2006) Tothill et al (2008)
Data set ID
 GSE3149
 GSE9891
Microarray platform
 Affymetrix U133A
 Affymetrix U133 Plus 2
Samples
 133
 285
Platinum/taxane
  
 243/195
Tumour grade (1/2/3/NA) 3/4/125/1 19/97/164/5
End point
  
 OS
 OS
 PFS
Gene set Gene set size      
All OV1002 carboplatin sets
 711
 0.0473
 0.00292
 0.000642
All OV1002 carboplatin/taxane sets
 3045
 0.128
 0.00101
 2.88E−05
All HOX424 carboplatin/taxane sets
 510
 0.00931
 0.000136
 0.000268
OV1002 carboplatin set 1 up early
 171
 0.421
 0.315
 0.87
OV1002 carboplatin set 2 down/up early
 169
 0.0406
 0.062
 0.00216
OV1002 carboplatin set 3 up late
 163
 0.577
 0.112
 0.059
OV1002 carboplatin set 4 down late
 213
 0.789
 0.589
 0.0935
OV1002 carboplatin/taxane set 1 up early
 733
 0.0936
 0.152
 0.463
OV1002 carboplatin/taxane set 2 down early
 533
 0.0257
 0.809
 0.0304
OV1002 carboplatin/taxane set 3 up late
 958
 0.263
 0.008
 6.48E−05
OV1002 carboplatin/taxane set 4 down late
 947
 0.0288
 0.0001
 4.71E−05
HOX424 carboplatin/taxane set 1 up late
 148
 0.0285
 0.468
 0.469
HOX424 carboplatin/taxane set 2 up late
 27
 0.869
 0.065
 0.532
HOX424 carboplatin/taxane set 3 down late
 119
 0.0398
 0.0003
 0.00126
HOX424 carboplatin/taxane set 4 down late
 226
 0.000463
 0.00009
 0.000102
KEGG apoptosis
 88
 0.00095
 0.776
 0.423
KEGG oocyte meiosis
 114
 0.647
 0.00654
 0.0203
KEGG progesterone-mediated oocyte maturation
 87
 0.886
 0.0114
 0.0847
KEGG p53 signalling pathway
 69
 0.372
 0.0139
 6.40E−05
KEGG cell cycle
 128
 0.0453
 0.138
 0.443
OV1002 carboplatin/taxane cell cycle
 51
 0.0438
 0.00814
 0.00301
OV1002 carboplatin/taxane set 1 up early cell cycle
 25
 0.0272
 0.00665
 0.00683
KEGG glutathione metabolism
 50
 0.0259
 0.00895
 0.726
KEGG neurotrophin signalling pathway
 126
 0.0282
 0.00133
 7.54E−06
KEGG β-alanine metabolism 22 0.0488 0.0414 0.000998

Abbreviations: KEGG=Kyoto encyclopedia of genes and genomes; NA=not assigned; OS=overall survival; PFS=progression-free survival. Significant P-values (P<0.05) are shown in bold.