Table 2.
Hemodynamics and abdominal pressures at baseline and at 150 and 300 minutes (median and range).
| CO | SB Healthy | ||||
|---|---|---|---|---|---|
| L/min | PEEP 5 Healthy | 3.8; 2.2-4.8 | 3.7; 2.4-4.4 | 3.7; 2.7-5.1 | |
| CPAP 5 LPS | 2.7; 1.9-3.0 | ||||
| PEEP 5 LPS | 2.6; 1.8-3.9 | 2.5; 1.7-5.3 | PEEP 5 LPS | 2.1; 1.8-2.93 | |
| PEEP 15 LPS | 1.9; 1.5-2.74 | ||||
| HR | SB Healthy | 109.5; 95-123 | 97.5; 81-105 | 97.5; 89-103 | |
| bpm | PEEP 5 Healthy | 107.0; 78-125 | 109.0; 76-132 | 107; 72-132 | |
| CPAP 5 LPS | 107.0; 93-117 | ||||
| PEEP 5 LPS | 88.2; 63-120 | 120.6; 87-1462 | PEEP 5 LPS | 105; 86-117 | |
| PEEP 15 LPS | 107.5; 95-127 | ||||
| MAP | SB Healthy | 82.5; 59-92 | 67.5; 60-71 | 68.5; 58-70 | |
| mm Hg | PEEP 5 Healthy | 72.5; 59-112 | 77.0; 56-103 | 83.0; 56-1111 | |
| CPAP 5 LPS | 88.5; 76-90 | ||||
| PEEP 5 LPS | 80.0; 57-115 | 74.2; 58-104 | PEEP 5 LPS | 81.0; 65-94 | |
| PEEP 15 LPS | 69.0; 59-78 | ||||
| CVP | SB Healthy | ||||
| mm Hg | PEEP 5 Healthy | 8.5; 6-9 | 9; 5-10 | 8.5; 5-9 | |
| CPAP 5 LPS | 6.5; 5-9 | ||||
| PEEP 5 LPS | 7.5; 5-9 | 7.2; 4-11 | PEEP 5 LPS | 9.0; 3-11 | |
| PEEP 15 LPS | 9.5; 9-134 | ||||
| MPAP | SB Healthy | ||||
| mm Hg | PEEP 5 Healthy | 18.0; 17-24 | 17.5; 15-26 | 17.0; 16-25 | |
| CPAP 5 LPS | 34.5; 29-38 | ||||
| PEEP 5 LPS | 16.3; 14-21 | 37.1; 25-482 | PEEP 5 LPS | 35.5; 25-45 | |
| PEEP 15 LPS | 33.5; 31-40 | ||||
| APP | SB Healthy | ||||
| mm Hg | PEEP 5 Healthy | 60.8; 44.5-100 | 63; 42-86.5 | 70.3; 43.5-96 | |
| CPAP 5 LPS | 68.5; 62-773 | ||||
| PEEP 5 LPS | 67.9; 37.5-69.5 | 55.7; 31-62 | PEEP 5 LPS | 63.8; 43-81 | |
| PEEP 15 LPS | 43.5; 31.6-65.0* | ||||
| IAP | SB Healthy | ||||
| mm Hg | PEEP 5 Healthy | 14.0; 5.5-18 | 13.5; 8-20 | 13.3; 8.5-21 | |
| CPAP 5 LPS | 17.5; 12-23.4 | ||||
| PEEP 5 LPS | 11.7; 5-25 | 19.0; 11-292 | PEEP 5 LPS | 16.0; 10-22 | |
| PEEP 15 LPS | 22.5; 13-31.5 |
Note that the pigs given endotoxin (LPS) were all ventilated with PEEP 5 for the first 150 minutes (2.5 hours) and then either maintained on MV + PEEP 5 or switched to MV + PEEP 15 or SB + CPAP 5 for the next 2.5 hours (until 300 minutes); n = 6 in all groups. Significances (P < 0.05) after correction for multiple comparisons (Bonferroni):
Comparison with:
1: SB Healthy
2: Baseline
3: 150 minutes
4: CPAP 5 LPS
5: PEEP 5 LPS
*Difference of borderline significance between MV + PEEP 15 and CPAP 5 (0.05 <P < 0.10; correction for multiple comparisons).