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. 2013 Jul 24;17(4):R161. doi: 10.1186/cc12840

Table 4.

Predictive values of pupil diameter variations for insufficient analgesia (RASS increase ≥1 point)

  10 mA tetanic stimulation 20 mA tetanic stimulation 40 mA tetanic stimulation
Best cutoff for pupil diameter variation (%)
1
5
13
Sensitivity
0.67 (0.52 – 0.81)
0.72 (0.58 – 0.86)
0.78 (0.65 – 0.91)
Specificity
0.73 (0.59 – 0.87)
0.77 (0.64 – 0.90)
0.86 (0.76 – 0.97)
Positive predictive value
0.67 (0.52 – 0.81)
0.72 (0.58 – 0.86)
0.82 (0.71 – 0.94)
Negative predictive value
0.73 (0.59 – 0.87)
0.77 (0.64 – 0.90)
0.83 (0.71 – 0.94)
Youden index 0.39 0.49 0.68

All data except Youden index were 95% confidence interval. RASS Richmond Agitation Sedation Scale.