Table 1.
Data regarding animals subjected to acute pneumonia-induced ALI
| Variable | Vehicle | 5 × 109 IκBα | 1 × 1010 IκBα | 5 × 1010 IκBα |
|---|---|---|---|---|
| Number of animals | 12 | 12 | 12 | 12 |
| Animal weight (g) | 456 ± 55 | 486 ± 54 | 469 ± 52 | 438 ± 86 |
| Bacteria instilled (CFU × 1010) | 1.1 ± 0.2 | 2.1 ± 0.2 | 2.6 ± 2.0 | 2.1 ± 2.2 |
| Baseline arterial PO2 (kPa) | 18.7 ± 0.5 | 18.7 ± 0.8 | 18.8 ± 0.8 | 18.7 ± 0.8 |
| Baseline static compliance (ml/mm Hg) | 0.93 ± 0.1 | 0.95 ± 0.1 | 0.99 ± 0.2 | 0.87 ± 0.2 |
| Animal survival (number, %) | 4 (33) | 7 (58) | 11 (92)* | 5 (42) |
| Duration of animal survival (hours) | 2.75(2, 4) | 4 (1.5, 4) | 4 (4, 4)* | 3 (1.75, 4) |
| Lung homogenate bacterial counts (CFU × 109) | 0.8 (0.4, 1.7) | 1.4 (0.2, 2.6) | 0.6 (0.4, 0.9) | 0.7 (0.4, 0.9) |
| BAL neutrophils (× 107/ml) | 5.9 (1.5, 8.4) | 3.7 (1.5, 8.9) | 6.2 (1.8, 6.7) | 8.5 (1.1, 9.1) |
| BAL mononuclear cells (× 107/ml) | 2.2 (1.4, 9.1) | 0.57 (2.7, 7.0) | 1.5 (1.2, 9.3) | 1.8 (1.1, 9.6) |
Note: Data are expressed as mean ± SD. *Significantly different from Vehicle group.