Table 5.
Overexpression of Null or IκBα transgenes does not alter lung function or activate the immune response in animals subjected to sham prolonged pneumonia-induced ALI
| Variable | Vehicle | IκBα transgene | Null transgene |
|---|---|---|---|
| Number of animals | 4 | 4 | 4 |
| Animal weight (g) | 411 ± 24 | 409 ± 14 | 395 ± 11 |
| Animal survival (n, %) | 4 (100%) | 4 (100%) | 4 (100%) |
| Duration of animal survival (hours) | 72 (72, 72) | 72 (72, 72) | 72 (72, 72) |
| Final arterial PO2 (kPa) | 18.3 ± 0.3 | 17.6 ± 2.5 | 18.3 ± 0.2 |
| Final static compliance (ml/mm Hg) | 0.71 ± 0.07 | 0.78 ± 0.09 | 0.75 ± 0.12 |
| BAL protein (mg/L) | 961 ± 221 | 829 ± 226 | 826 ± 180 |
| BAL neutrophils (× 103/ml) | 1.1 ± 0.7 | 2.2 ± 1.7 | 1.4 ± 1.2 |
| BAL mononuclear cells (× 104/ml) | 5.5 ± 3.6 | 5.2 ± 3.9 | 3.8 ± 2.4 |
Data are expressed as mean ± SD or median [interquartile range]. Final data are data collected on completion of the experimental protocol. *Significantly different from Vehicle group. BAL, bronchoalveolar lavage; CFU, colony-forming units