Table 1.
Baseline Characteristics
| Characteristic | No. (%) |
P Value |
|
|---|---|---|---|
| Quintiles 1–2 |
Quintiles 3–5 |
||
| Total No. | 852 | 1279 | |
| BDNF, mean (SD), ng/mL | 15 242 (4033) | 28 240 (5972) | |
| Age, mean (SD), y | 72.8 (7.6) | 72.1 (7.5) | .03 |
| Women | 242 (50) | 775 (61) | <.001 |
| College degree | 231 (28) | 296 (24) | .04 |
| Systolic blood pressure, mean (SD), mm Hg | 135 (20) | 136 (20) | .56 |
| Antihypertensive medication | 389 (45.8) | 584 (45.8) | .99 |
| Current smoker | 52 (6) | 115 (9) | .02 |
| Diabetes mellitus | 145 (17) | 185 (15) | .11 |
| Prevalent cardiovascular disease | 192 (23) | 255 (20) | .15 |
| Atrial fibrillation | 77 (9) | 66 (5) | <.001 |
| Total cholesterol, mean (SD), mg/dL | 195 (36) | 204 (37) | <.001 |
| Total homocysteine, median (IQR), µmol/L | 9.0 (4.3) | 9.0 (3.9) | .09 |
| Depression (CES-D score), median (IQR) | 3.0 (6.0) | 3.0 (6.0) | .23 |
| Physical Activity Index, median (IQR) | 35.7 (8.0) | 35.8 (8.2) | .18 |
Abbreviations: BDNF, brain-derived neurotrophic factor; CES-D, Center for Epidemiological Studies Depression Scale; IQR, interquartile range.