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. 2014 Jul;96(1):123–131. doi: 10.1189/jlb.3A1013-541R

Figure 6. Survival and release of IL-27(p28) in Tyk2−/− mice following endotoxic shock.

Figure 6.

(A) Survival of WT mice (n=9) and Tyk2−/− mice (n=9) during endotoxic shock following injection with LPS (10 mg/kg body weight i.p.). (B) Body-surface temperature of WT mice and Tyk2−/− mice, 24 h after LPS injection of the experiment described above. (C) Plasma concentrations of IFN-β following endotoxic shock (1 and 3 h) in WT mice and Tyk2−/− mice (n=6/group); ELISA. (D) Detection of IL-27(p28) in plasma during endotoxic shock in WT mice (n=7) and Tyk2−/− mice (n=8); 6 h; ELISA. Survival curves were analyzed using the log-rank (Mantel-Cox) test, and frames (B–D) were analyzed using the nonparametric Mann-Whitney test. *P < 0.05; **P < 0.01.