Skip to main content
. 2014 Jul;96(1):123–131. doi: 10.1189/jlb.3A1013-541R

Figure 7. Survival and release of IL-27(p28) in Tyk2−/− mice during polymicrobial sepsis following CLP.

Figure 7.

(A) Survival of WT mice (n=16) and Tyk2−/− mice (n=17) in polymicrobial sepsis following CLP (“high-grade”). (B) Body-surface temperature of WT mice (n=16) and Tyk2−/− mice (n=16), 24 h after CLP from the same experiment described in A. (C) Plasma concentrations of IL-27(p28), 10 h after CLP in WT mice (n=7) and Tyk2−/− mice (n=8). Survival curves were analyzed using the log-rank (Mantel-Cox) test, and frames (B and C) were analyzed using the nonparametric Mann-Whitney test. **P < 0.01; ****P < 0.0001.