Table 1B.
Nuclear volume correction.
Mouse lines | WT | G2 | G2 + KN62 | G2 + KN93 | G2 + KN92 |
---|---|---|---|---|---|
Nuclear volume | 8607 ± 508 | 14000 ± 580 | 9950 ± 695 | 9900 ± 532 | 15000 ± 530 |
Fibroblasts from Wild type (WT) and G2 transgenic mouse have been cultured for 24 h with or without CamKII inhibitors (KN62 and KN93). KN 92 a molecule similar to KN93 but inactive on CamKII, has also been used. Nuclear volume has been evaluated using the Imagej software. Data have been analyzed using the Mann-Whitney test, demonstrating that differences are not statistically different between cells treated with KN92 and wild type but are highly statistically significant between non-treated and cells treated either with KN62 or KN 93. (p-Value < 0.0001). This experiment has been repeated three time.