Table 1.

Endogenous HMGB1-inhibiting agents.

Agents	Infection Models	Injury Models
Neutralizing antibodies	LPS/CLP	Atherosclerosis
		Crush
		Chemical toxemia
		Liver I/R
		Brain I/R
		Heart I/R
		Hyperoxia
		Hemorrhagic
		Trauma
		Ulcer
Anti-coagulant agents
Anti-thrombin III	LPS	Ischemia
Thrombomodulin	LPS	I/R
		Heatstroke
Acute phase proteins
Fetuin-A	LPS/CLP	Cerebral Ischemia
		Burn
Endogenous hormones
Vasoactive intestinal peptide	CLP	Ischemia
		Hemorrhagic injury
Ghrelin	CLP	Intestinal I/R
		Hypoxia
		Radiation
Intravenous immunoglobulin	CLP	Cerebral Ischemia

Note: LPS, lipopolysaccharide; CLP, cecal ligation and puncture; I/R, ischemia/reperfusion