Table 2.
Interaction partners of neurexins
| Protein | Binding site |
Requirement for |
Reference(s) | |
|---|---|---|---|---|
| Splice insert | Ca 2+ binding | |||
| Binding partners specific for α-Nrxn: | ||||
| Neurexophilin |
αLNS2 |
- |
- |
[17,19,128] |
| Shared by α-Nrxn and β-Nrxn: | ||||
| Neuroligin |
αLNS6, βLNS |
(−/+)SS#4 |
+ |
[15,16,54] |
| Dystroglycan |
αLNS2, αLNS6, βLNS |
-SS#2, -SS#4 |
+ |
[20] |
| GABA(A)R |
αLNS6, βLNS |
-SS#4 |
|
[8] |
| LRRTM |
αLNS6, βLNS |
-SS#4 |
+ |
[21,22] |
| Cerebellin |
αLNS6, βLNS |
+SS#4 |
- |
[23,24] |
| Synaptotagmin |
Cytosolic domain |
- |
+ |
[80] |
| Znf804a |
Cytosolic domain |
- |
- |
[129] |
| CASK |
PDZ motif |
- |
- |
[77,78] |
| Mint/X11/Apba |
PDZ motif |
- |
- |
[78] |
| AF-6 | PDZ motif | - | - | [130] |
Summary of binding partners of α-neurexins and β-neurexins (Nrxn). Note that neuroligins preferentially bind to neurexins without insert in splice site 4 (−SS#4) and that binding is modified by the presence of + SS#4 as discussed in the main text. Of all currently known interaction partners only neurexophilins bind exclusively to α-neurexin [17]. Neurexophilins are expressed only in distinct neuronal populations in the brain [18,19,128,131] but may modulate the function of their cognate α-neurexin receptors [18,128]. LNS, laminin-neurexin-sex hormone binding globulin.