Table 3.

Comparison between night and day periods of time to achieve each component of the 6-h bundle (hours)

6-h bundle component	Day, h	Night, h	P value
Serum lactate measurement, median (IQR)	6:97 (1:27-25:18)	4:48 (0:83-14:02)	0.018*
Blood cultures drawn, median (IQR)	8:17 (2:74-25:54)	4:06 (1:55-10:83)	<0.001*
Antibiotic administration, median (IQR)	8:18 (4:25-16:17)	4:95 (2:02-9:89)	<0.001*
CVP >8 mmHg, median (IQR)	10:94 (5:17-22:50)	7:83 (1:88-17:37)	0.010*
SvcO2 >70%, median (IQR)	10:65 (8:78-22:17)	2:47 (1:02-29:64)	0.222*

^aMann-Whitney test.

CVP: Central venous pressure; IQR: Interquartile range; SvcO2: Central venous oxygen saturation.