Table 1.

Linear mixed models for renal blood flow (RBF) and cerebral blood flow (CBF).

RBF	Coefficient	95% confidence interval	P
Fixed effects
MAP (mmHg)	0.05	0.01; 0.15	<0.001
NE infusion	-0.90	-1.24; -0.57	<0.001
Sepsis	-0.26	-0.72; 0.2	0.3
Interaction MAP×T100 mmHga	-0.01	-0.01; -0.001	0.001
Random effects
Interindividual standard deviation	0.78	0.61; 0.98
Intraindividual standard deviation
Control	1.45	1.27; 1.7	<0.0001a
Sepsis	0.9	0.81; 1
NE infusion	0.53	0.46; 0.6
NE+Sepsis	0.39	0.35; 0.44
CBF	Coefficient	95% confidence interval	P
Fixed effects
MAP (mmHg)	0.02	0.02; 0.03	<0.001
NE infusion	1.83	1.24; 2.40	<0.001
Sepsis	0.76	0.15; 1.37	0.01
Interaction MAP × NEc	-0.02	-0.02; -0.01	<0.001
Interaction MAP×T100 mmHga	0.013	0.01; 0.002	<0.001
Random effects
Interindividual standard deviation	0.99	0.77; 1.27
Intraindividual standard deviation
Control	1.01	0.88; 1.16	<0.001a
Sepsis	0.91	0.8; 1.03
NE infusion	0.38	0.33; 0.43
NE+Sepsis	0.62	0.55 ; 0.7

^aInteraction MAP × threshold 100 mmHg.

^bFor between-groups comparison.

^cInteraction MAP × NE infusion.

MAP: mean arterial pressure; NE: norepinephrine.