Table 1.
Comparison of biological parameters in patients as a function of the 30% median threshold of ADAMTS13 activity
| Median (IQR) or number (%) | Patients with ADAMTS13 activity <30% (n = 36) | Patients with ADAMTS13 activity >30% (n = 36) | P -value |
|---|---|---|---|
| DIC |
11 (31%) |
8 (22%) |
0.59 |
| ISTH score |
3 (2, 5) |
3 (1, 4) |
0.58 |
| Platelet count, day 1 |
61 (27, 199) |
136 (29, 191) |
0.47 |
| Platelet count <65 G/L |
17 (47.2%) |
20 (56%) |
0.05 |
| ADAMTS13:Ag, ng/mL |
457 (374, 496) |
533 (413, 680) |
0.15 |
| Positive anti-ADAMTS13 IgG |
3 |
4 |
NA |
| Anti-ADAMTS13 inhibitor |
0 |
0 |
NA |
| VWF:Ag, % |
492 (369, 642) |
560 (402, 700) |
0.42 |
| IL-6, pg/mL | 895 (330, 1843) | 83 (43, 118) | 0.0003 |
Values are expressed as median and IQR for continuous variables and as number and proportion for categorical variables. Continuous variables were compared using the non-parametric Mann–Whitney U-test. Categorical variables were compared using the χ2 test. P <0.05 was considered significant. DIC, disseminated intravascular coagulation; ISTH: International Society for Thrombosis and Haemostasis; ADAMTS13, a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13; Ig, immunoglobulin; VWF:Ag, von Willebrand Factor antigen; NA, statistical test not performed.