Table 2.
Severity of disease at presentation and outcome according to the number of hemostatic abnormalities in 72 patients with septic shock
| Median (IQR) or number (%) | Group 1, n = 28 (no DIC or ADAMTS13 activity >30% a ) | Group 2, n = 33 (either DIC or ADAMTS13 activity <30% a ) | Group 3, n = 11 (both DIC and ADAMTS13 activity <30% a ) | P -value |
|---|---|---|---|---|
| ISTH score |
3 (2, 4) |
3 (2, 5) |
5 (5, 7) |
0.01 |
| ADAMTS13 activity |
46% (39, 79) |
24% (19, 54) |
15% (9, 25) |
0.002 |
|
Severity of disease |
|
|
|
|
| LOD score, day 1 |
7 (4, 9) |
7 (6, 10) |
13 (7, 14) |
0.02 |
| SAPS II score, day 1 |
48 (38, 65) |
62 (47, 69) |
77 (51, 95) |
0.01 |
| Systolic blood pressure, mmHg |
85 (80, 91) |
80 (67, 86) |
72 (67, 76) |
0.004 |
| PaO/FiO2 |
240 (116, 300) |
140 (110, 245) |
95 (76, 127) |
0.02 |
| Lactates, mmol/L |
2.6 (2.0, 5.6) |
3 (1.9, 6.3) |
6.4 (1.9, 16.5) |
0.06 |
| IL-6 concentration, pg/mL |
78 (46, 126) |
318 (94, 1003) |
1,835 (500, 3,030) |
0.004 |
|
Outcome |
|
|
|
|
| Need for mechanical ventilation |
19 (68) |
26 (79) |
10 (91) |
0.25 |
| Persistent shock, day 3 |
10 (35.7) |
26 (79) |
11 (100) |
0.001 |
| Need for RRT |
8 (28.6) |
10 (30.3) |
5 (45.3) |
0.24 |
| Continuous hemofiltration |
2 (7.1) |
6 (18.2) |
4 (36.3) |
0.09 |
| Dotrecogrin alpha activated |
2 (7.1) |
0 |
0 |
0.19 |
| Stress dose steroids |
6 (21.4) |
6 (18.2) |
1 (9) |
0.64 |
| Length of ICU stay |
5 (3, 13) |
5 (3, 13) |
6 (2, 15) |
0.95 |
| ICU mortality |
6 (21.4) |
18 (54.5) |
5 (45.4) |
0.02 |
| Hospital mortality | 28.6% | 71% | 75% | 0.007 |
Values are expressed as median and IQR for continuous variables and as proportion for categorical variables. Continuous variables were compared using the non-parametric Kruskall-Wallis test. Categorical variables were compared using thea χ2 test. P <0.05 was considered significant. The normal range for ADAMTS13 activity is 50 to 150%. a30% corresponds to the median of ADAMTS13 activity in the 72 patients with septic shock. DIC, disseminated intravascular coagulation; ISTH: International Society for Thrombosis and Haemostasis; ADAMTS13, a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13; LOD, logistic organ dysfunction; SAPS II, Simplified Acute Physiology Score II; PaO/FiO2, arterial partial pressure of oxygen/inspired oxygen fraction; RRT, renal replacement therapy.