Fig. 2.

Mefloquine effects on VTA dopamine neuron sIPSC frequency, amplitude, and interevent interval in WT and Cx36 KO mice. This figure compares WT (A–C) and KO (D–F) VTA DA neuron sIPSC data after being presoaked with either MFQ (25 μM), CBX (100 μM), ODS (25 μM), or MFQ (25 μM) 1 MEC (10 μM) for ≥60 min. In WT mice (C), sIPSCs were increased similarly by MFQ (533%) and MFQ+MEC (488%), CBX alone increased sIPSC frequency 211%, but ODS alone did not mimic MFQ. MFQ and MFQ+MEC shifted the interevent interval curve to the left (B), while CBX alone shifted the curve slightly to the left. In Cx36 KO mice, only MFQ increased sIPSC frequency (F) and shifted the interevent interval curve to the left (E). MFQ's increase of Cx36 KO mouse sIPSC frequency was about half of its increase of WT sIPSC frequency.