Figure 8.

(A) A simulation of a total body weight based dosage of a bolus and infusion for 30 kg pig. Propofol’s kinetic parameters are from Johnson et al.¹³ The propofol dosing scheme was designed to achieve peak concentrations near the effect site concentration estiamted to produce 50% of maximal effect (i.e., the Ce₅₀). AZD-3043 dosing scheme (3-fold higher than propofol) was based on the current experiment design (1.5 mg·kg⁻¹·min⁻¹ for AZD-3043 vs. 0.5 mg·kg⁻¹·min⁻¹ for propofol). (B) A simulation of the time necessary to achieve a 80% or 50% decrease in effect site concentration after the termination of a continuous infusion targeting a constant concentration.