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The in vitro stability of AZD-3043 in various spieces.
| Preparation | Species | Mean t1/2 value (minutes) |
|---|---|---|
| Liver microsomes | Human | 4 |
| Dog | 7 | |
| Minipig | 0.4 | |
| Cynomolgus monkey | 3 | |
| Whole blood | Human | 27 ± 8* |
| Cat | >60 | |
| Dog | >60 | |
| Minipig | >60 | |
| Rat | 0.6 | |
| Guinea pig | 0.1 |
Data are expressed with respect to the mean t1/2 values from at least two separate studies.
Human whole blood stability experiments were conducted in whole blood from seven separate human donors.
