Table 1.
Characteristics of patients with ARDS based on the Berlin definition on the day of enrollment.
| mild ARDS (n = 47) |
moderate ARDS (n = 82) |
severe ARDS (n = 66) |
|
|---|---|---|---|
| Age, years | 68 (59-78) | 68 (59-82) | 67 (53-78) |
| Gender (male), % (n) | 70.2% (n = 33) | 63.4% (n = 52) | 66.7% (n = 44) |
| APACHE II score, points | 19 (13-25) | 25 (20-28)* | 25 (18-30)* |
| SOFA score, points | 9 (6-12) | 11 (9-13)* | 11 (10-14)* |
| SIRS criteria | 2.0 (1.0-3.0) | 2.0 (1.8-3.0) | 3.0 (2.0-3.0)** |
| FIO2 | 0.5 (0.4-0.6) | 0.6 (0.5-0.8)* | 1.0 (0.8-1.0)*# |
| PEEP, cmH2O | 8 (5-10) | 10 (6-12) | 10 (6-12) |
| PaO2/FIO2 ratio, mm Hg | 247 (217-280) | 148 (122-173)* | 76 (60-90)*# |
| GEDI, mL/m2 | 780 (662-975) | 814 (711-925) | 730 (620-952) |
| EVLWi, mL/kg | 16.1 (12.2-18.1) | 17.2 (12.9-22.9) | 19.1 (14.4-22.9)** |
| PVPI | 2.7 (2.2-3.2) | 3.0 (2.4-3.6) | 3.2 (2.6-4.1)*## |
| Ventilator-free days within 28 days |
18 (0-20) | 9 (0-19) | 4 (0-19) |
| 28-day mortality, % (n) | 23.4% (n = 11) | 43.9% (n = 36)** | 42.4% (n = 28)** |
*P <0.01 vs. mild ARDS; **P <0.05 vs. mild ARDS; #P <0.01 vs. moderate ARDS; ##P <0.05 vs. moderate ARDS. ARDS, acute respiratory distress syndrome; APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; SIRS, systemic inflammatory response syndrome; PEEP, positive end-expiratory pressure; GEDI, global end-diastolic blood volume index; EVLWi, extravascular lung water index; PVPI, pulmonary vascular permeability index.