Table 1.
Baseline characteristics of all 562 patients included in the study
|
Non-DIC |
JAAM DIC |
P value | ||
|---|---|---|---|---|
| (n = 257) | ISTH (−) (n = 210) | ISTH (+) (n = 95) | ||
| Age (years) |
48 ± 20 |
49 ± 23 |
49 ± 25 |
0.682 |
| Sex (male/female) |
64/193 |
76/134 |
43/52 |
0.001 |
| Injury Severity Score |
20.7 ± 11.5 |
25.7 ± 13.0 |
35.3 ± 13.0 |
0.000 |
| APACHE II score |
13.9 ± 7.2 |
19.7 ± 8.2 |
26.1 ± 8.1 |
0.000 |
| SOFA score |
5.0 ± 2.2 |
6.5 ± 3.3 |
10.2 ± 3.6 |
0.000 |
| SIRS criteria |
2.8 ± 0.8 |
3.4 ± 0.7 |
3.0 ± 0.9 |
0.000 |
| JAAM DIC score (day 0) |
1.5 ± 1.0 |
4.7 ± 1.0 |
6.7 ± 1.3 |
0.000 |
| ISTH DIC score (day 0) |
1.2 ± 1.2 |
3.3 ± 0.6 |
5.9 ± 1.0 |
0.000 |
| MODS (yes/no) |
2/255 |
22/188 |
41/54 |
0.000 |
| Outcome (survived/died) |
248/9 |
174/36 |
54/41 |
0.000 |
| FDP/D-dimer ratio |
1.6 ± 0.9 |
1.8 ± 0.7 |
4.3 ± 19.8 |
0.000 |
| Lactate (mM) | 3.2 ± 1.9 | 4.9 ± 3.2 | 8.2 ± 5.1 | 0.000 |
APACHE, Acute Physiology and Chronic Health Evaluation; DIC, disseminated intravascular coagulation; FDP, fibrin fibrinogen degradation products; FFP, fresh frozen plasma; ISTH, International Society on Thrombosis and Haemostasis; JAAM, Japanese Association for Acute Medicine; MODS, multiple organ dysfunction syndrome; PRBCs, packed red blood cells; SIRS, systemic inflammatory response syndrome; SOFA, Sequential Organ Failure Assessment. ISTH (−) (+), JAAM DIC patients who did not meet the ISTH overt DIC criteria and those who simultaneously met the ISTH overt DIC criteria, respectively. P value, Kruskal-Wallis test.