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. 2014 Feb 9;18(1):R28. doi: 10.1186/cc13719

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Copyright © 2014 Schellekens et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Course of blood pH, CO_2,O₂and MAP during 18 hours of mechanical ventilation. (a) As expected increasing Fico₂ reduces blood pH. *Two-way repeated measure analysis showed that pH values over time were significantly different between groups. (b) CO₂ was significantly increased at the end of experiment in hypercapnic rats. *Two-way repeated measure analysis showed that CO₂ values over time were significantly different between groups. (c) O₂ was not significantly different between mechanically ventilated groups. (d) MAP was significantly lower at 4 hours and at the end of experiment in hypercapnic rats. *Two-way repeated measure analysis showed that MAP was significantly different between groups at 4, 12, 16 and 18 hours of mechanical ventilation. MAP, mean arterial pressure.