FIGURE 4.

Infarct size in apoA1^−/−mice was reduced to that of WT mice by CoQ10 supplementation. WT (circles) and apoA1^−/−(squares) mice were administered vehicle or CoQ10 (0.1 mg · g⁻¹ · d⁻¹) i.p. for 3 d before left anterior descending coronary artery ligation. Infarct size as a function of area at risk was determined as in Figure 1 (mean ± SD; n = 4 per group; *P < 0.05 vs. corresponding untreated mice). Values are individual data points, with bars representing means. ApoA1^−/−, apoA1 null; CoQ10, coenzyme Q10; WT, wild-type.