TABLE 2.
Bivariate and multivariate analysis of the outcome >50% ulcer area reduction at T6
| Bivariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variable | >50% area reduction at T6 (N=55) | No >50% area reduction at T6 (N=82) | Relative risk (95%CI) | p-value | Relative risk (95%CI) | p-value |
| Female sexa | 34 (62) | 62 (76) | 0.70 (0.47-1.06) | 0.09 | ||
| Patient age,bin years | 58 (50-69) | 61 (52-72) | 0.99 (0.98-1.00) | 0.14 | ||
| Duration of active ulcer,bin years | 3 (2-7) | 5 (2-17) | 0.97 (0.93-1.00) | 0.09 | 0.95 (0.91-0.98) | 0.01 |
| Ulcer locationa | 0.55 | |||||
| Medial | 25 (46) | 23 (28) | 1.76 (0.92-3.37) | |||
| Lateral | 12 (22) | 22 (27) | 1.43 (0.69-2.98) | |||
| Anterior | 8 (15) | 16 (20) | 1.42 (0.65-3.12) | |||
| Other / More than one | 10 (18) | 21 (26) | 1.00 (-) | |||
| Area at baseline,bin cm2 | 7 (4-25) | 20 (4-87) | 1.00 (0.99-1.00) | 0.21 | 1.00 (0.99-1.00) | 0.16 |
| Critical colonizationa | 15 (27) | 33 (40) | 0.69 (0.42-1.15) | 0.15 | ||
| Infectiona | 8 (15) | 27 (33) | 0.47 (0.24-0.92) | 0.03 | 0.42 (0.23-0.76) | 0.01 |
| Post-thrombotic etiologya | 9 (16) | 9 (11) | 1.10 (0.61-1.97) | 0.76 | ||
| Hypertensiona | 24 (44) | 42 (51) | 0.80 (0.52-1.23) | 0.32 | ||
| Diabetes mellitusa | 24 (44) | 42 (51) | 0.80 (0.52-1.23) | 0.32 | ||
| Compliance with resta | 39 (71) | 49 (60) | 1.21 (0.76-1.91) | 0.42 | ||
| Compliance with occlusive dressingsa | 46 (84) | 76 (93) | 0.68 (0.42-1.09) | 0.11 | 1.18 (0.42-3.30) | 0.75 |
| Compliance with compression therapya | 39 (71) | 47 (57) | 1.25 (0.79-1.98) | 0.34 | 4.04 (1.31-12.41) | 0.02 |
| Duration of debriding dressing use,b in months | 1 (0-4) | 2 (0-9) | 0.97 (0.92-1.01) | 0.13 | ||
| Duration of topical antibiotic use,bin months | 0 (0-0) | 0 (0-2) | 1.02 (0.97-1.07) | 0.49 | ||
| Therapeutic use of systemic antibioticsa | 9 (16) | 28 (34) | 0.33 (0.15-0.76) | 0.01 | ||
a
Qualitative variable expressed as N (%);
b
Quantitative variable expressed as median and interquartile range (IQR)