TABLE 3.
Bivariate and multivariate analysis of the outcome >50% ulcer area reduction at T12
| Bivariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variable | >50% area reduction at T12 (N=68) | No >50% area reduction at T12 (N=69) | Relative risk (95%CI) | p-value | Relative risk (95%CI) | p-value |
| Female sexa | 47 (69) | 49 (71) | 0.96 (0.67-1.38) | 0.83 | ||
| Patient age,bin years | 60 (49-73) | 60 (52-69) | 1.00 (0.99-1.00) | 0.91 | ||
| Duration of active ulcer,bin years | 3 (1-6) | 6 (3-18) | 0.95 (0.92-0.99) | 0.01 | 0.95 (0.92-0.98) | 0.02 |
| Ulcer locationa | 0.74 | |||||
| Medial | 25 (37) | 27 (33) | 1.28 (0.75-2.19) | |||
| Lateral | 19 (28) | 15 (22) | 1.51 (0.87-2.61) | |||
| Anterior | 11 (16) | 13 (19) | 1.42 (0.78-2.58) | |||
| Other / More than one | 13 (19) | 18 (26) | 1.00 (-) | |||
| Area at baseline,bin cm2 | 10 (4-38) | 13 (5-82) | 0.99 (0.99-1.00) | 0.18 | ||
| Critical colonizationa | 19 (28) | 29 (42) | 0.76 (0.51-1.15) | 0.19 | ||
| Infectiona | 14 (21) | 21 (30) | 0.63 (0.38-1.04) | 0.07 | ||
| Post-thrombotic etiologya | 10 (15) | 8 (12) | 1.02 (0.61-0.69) | 0.95 | ||
| Hypertensiona | 29 (43) | 37 (54) | 0.82 (0.58-1.17) | 0.28 | ||
| Diabetes mellitusa | 12 (18) | 19 (28) | 0.81 (0.51-1.28) | 0.36 | ||
| Compliance with resta | 45 (66) | 43 (62) | 1.08 (0.75-1.56) | 0.68 | ||
| Compliance with occlusive dressingsa | 61 (90) | 61 (88) | 1.15 (0.65-2.03) | 0.64 | ||
| Compliance with compression therapya | 43 (63) | 43 (62) | 0.97 (0.68-1.39) | 0.88 | ||
| Duration of debriding dressing use,bin months | 1 (0-4) | 2 (0-9) | 0.97 (0.92-1.01) | 0.13 | ||
| Duration of topical antibiotic use,b in months | 0 (0-0) | 0 (0-3) | 0.95 (0.89-1.02) | 0.15 | 0.93 (0.87-0.99) | 0.05 |
| Therapeutic use of systemic antibioticsa | 14 (21) | 23 (33) | 0.66 (0.40-1.09) | 0.10 | 0.63 (0.40-0.99) | 0.05 |
a
Qualitative variable expressed as N (%);
b
Quantitative variable expressed as median and interquartile range (IQR)