Table 1.
Characteristics of various types of pluripotent stem cells
| Stem cell type | Donor cell type | Reprogramming factors/systems | Teratoma formation | Chimera formation |
Pluripotency marker expression |
Reference | ||
|---|---|---|---|---|---|---|---|---|
| SSEA1 | SSEA3/4 | OCT4,SOX2, NANOG | ||||||
| MESCs |
Embryo |
- |
+ |
+ |
+ |
- |
+ |
[9] |
| HESCs |
Embryo |
- |
+ |
ND |
- |
+ |
+ |
[7] |
| MEpiSCs |
Epiblast |
- |
+ |
- |
+ |
- |
+ |
[90] |
| MiPSCs |
Neural stem cell |
OCT4, viral |
+ |
+ |
+ |
_ |
+ |
[91] |
| HiPSCs |
Amnion |
SOX2, plasmid electroporation |
+ |
ND |
- |
+ |
+ |
[82] |
| MiPSCs-C |
Melanoma |
OCT4, c-MYC, KLF4, viral |
+ |
+ |
ND |
ND |
ND |
[43] |
| HiPSCs-C |
Colorectal cancer |
OCT4, c-MYC, SOX2, KLF4, viral |
+ |
ND |
- |
+ |
+ |
[92] |
| HiPSCs-C | Melanoma | miRNA, viral | + | ND | - | + | + | [93] |
Human and murine pluripotent stem cells are characterized as described in the cited references. HESCs, human embryonic stem cells; HiPSCs, human induced pluripotent stem cells; HiPSCs-C, human induced pluripotent stem cells from cancer; MEpiSCs, murine epiblast stem cells; MESCs, murine embryonic stem cells; MiPSCs, murine induced pluripotent stem cells; MiPSCs-C, murine induced pluripotent stem cells from cancer; ND, not determined.