Table 2.
General hemodynamics
| |
Control |
Metabolic acidosis |
Respiratory acidosis |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline st | Baseline end | Δ | Baseline | Acidosis | Δ | Baseline | Acidosis | Δ | |
| HR |
101 ± 20 |
119 ± 39 |
|
93 ± 12 |
161 ± 56 |
↑ |
99 ± 25 |
200 ± 42 |
↑ |
| SV |
44.8 ± 8.7 |
44.2 ± 18.4 |
|
51.6 ± 11.9 |
34.1 ± 13.4 |
↓ |
48.2 ± 17.4 |
35.2 ± 8.4 |
↓ |
| GEDV |
660.4 ± 116.2 |
691.1 ± 123.6 |
|
620.3 ± 136.6 |
571.8 ± 125.1 |
|
709.1 ± 152.9 |
693.7 ± 113.6 |
|
| CO |
4.5 ± 0.8 |
4.8 ± 1.2 |
|
4.8 ± 1.1 |
5.3 ± 2.0 |
|
4.5 ± 1.1 |
7.3 ± 1.8 |
↑ |
| MAP |
94.5 ± 15.6 |
97.3 ± 16.9 |
|
87.4 ± 15.3 |
99.7 ± 18.4 |
|
88.7 ± 5.6 |
105.6 ± 9.4 |
↑ |
| CVP |
11.1 ± 2.1 |
10.6 ± 2.6 |
|
9.0 ± 2.6 |
9.3 ± 2.4 |
|
12.1 ± 3.8 |
12.1 ± 1.1 |
|
| MPAP |
25.1 ± 5.2 |
26.1 ± 3.9 |
|
23.1 ± 3.1 |
42.9 ± 8.4 |
↑ |
24.4 ± 1.7 |
40.3 ± 6.7 |
↑ |
| PCWP |
9.5 ± 1.9 |
9.3 ± 2.4 |
|
7.9 ± 2.5 |
9.3 ± 2.7 |
|
10.9 ± 1.2 |
9.3 ± 2.4 |
|
| SVR |
1,539 ± 409 |
1,520 ± 489 |
|
1,350 ± 327 |
1,564 ± 729 |
|
1,412 ± 327 |
1,068 ± 209 |
↓ |
| PVR |
287 ± 71 |
301 ± 142 |
|
268 ± 92 |
591 ± 283 |
↑ |
259 ± 60 |
356 ± 116 |
↑ |
| ITBV |
825.5 ± 145.3 |
863.9 ± 154.5 |
|
796 ± 173.3 |
715.9 ± 168.9 |
↓ |
886.4 ± 191.1 |
867.1 ± 142 |
|
| LVSW |
59.5 ± 17.2 |
52.8 ± 20 |
|
61.8 ± 17.9 |
45.6 ± 18 |
|
58.4 ± 24.9 |
55.4 ± 12.4 |
|
| LVSWtot |
6,056 ± 1,606 |
6,183 ± 1,783 |
|
5,784 ± 1,924 |
7,179 ± 2,835 |
|
5,788 ± 1,368 |
11,124 ± 2,968 |
↑ |
| RVSW |
15.5 ± 4.5 |
13.7 ± 4.5 |
|
16.3 ± 5.6 |
20.4 ± 10.8 |
|
16.7 ± 7.9 |
21.1 ± 7.3 |
|
| RVSWtot |
1,606 ± 541 |
1,618 ± 419 |
|
1,492 ± 420 |
3,088 ± 1,414 |
↑ |
1,650 ± 539 |
4,166 ± 1,313 |
↑ |
| HVSW |
7,662 ± 2,041 |
7,801 ± 2,146 |
|
7,276 ± 2,201 |
10,267 ± 4,086 |
|
7,438 ± 1,874 |
15,290 ± 4,135 |
↑ |
| Hearte | 417.6 ± 111.2 | 425.2 ± 117 | 396.6 ± 120 | 559.6 ± 222.7 | 405.4 ± 102.1 | 833.4 ± 225.4 | ↑ | ||
↑, significantly increased, P < 0.05; ↓, significantly decreased, P < 0.05; HR, heart rate (bpm); SV, stroke volume (ml); GEDV, global end-diastolic volume (ml); CO, cardiac output (L/min); MAP, mean arterial pressure (mm Hg); CVP, central venous pressure (mm Hg); MPAP, mean pulmonary artery pressure (mm Hg); PCWP, pulmonary capillary wedge pressure (mm Hg); SVR, systemic vascular resistance (dyne s/cm-5); PVR, pulmonary vascular resistance (dyne s/cm-5); ITBV, intrathoracic blood volume (ml); LVSW, left ventricular stroke work (cJ), calculated as 0.0136 × MAP × SV; LVSWtot, left ventricular stroke work per minute (cJ/min); RVSW, right ventricular stroke work (cJ), calculated as 0.0136 × MPAP × SV; RVSWtot, right ventricular stroke work per minute (cJ/min); HVSW, (complete) heart ventricular stroke work per minute (cJ/min); heartE, heart energy (kcal).