Table 1.
Baseline data
| Variable |
Sham |
Sham + HF |
CPB |
CPB + HF |
ANOVA |
|---|---|---|---|---|---|
| (n = 8) | (n = 6) | (n = 8) | (n = 6) | P value | |
| Weight (kg) |
57.0 (1.4) |
66.2 (4.1) |
56.4 (1.4) |
72.9 (1.8) |
0.001 |
| Serum creatinine (μmol/l) |
138.8 (9.7) |
136.2 (5.9) |
132.3 (7.0) |
136.8 (5.6) |
0.937 |
| Urine output (ml/kg/hour) |
1.1 (0.17) |
1.3 (0.22) |
1.9 (0.40) |
1.6 (0.30) |
0.209 |
| Creatinine clearance (ml/minute) |
103.2 (8.2) |
116.5 (17.1) |
116.4 (12.9) |
122.7 (19.9) |
0.791 |
| Creatinine clearance adjusted for body weight (ml/minute/kg) |
1.7 (0.2) |
1.6 (0.2) |
2.1 (0.2) |
1.6 (0.3) |
0.327 |
| Serum total cholesterol (mmol/l) |
1.5 (0.9) |
15.3 (2.5) |
1.5 (0.8) |
12.8 (3.4) |
<0.001 |
| Mean arterial blood pressure (mmHg) |
81.1 (2.6) |
73.7 (1.7) |
82.4 (2.4) |
71.7 (1.5) |
0.062 |
| Perioperative fluid administration (ml) |
5,000 (4,750 to 5,000) |
5,000 (5,000 to 5,000) |
5,500 (5,000 to 6,000) |
5,125 (3,500 to 5,500) |
0.230 |
| Baseline haemoglobin (g/dl) |
8.7 (0.4) |
10.1 (0.2) |
8.9 (0.3) |
9.2 (0.6) |
0.064 |
| Perioperative metaraminol dosage (mg) |
0 (0 to 0) |
0 (0 to 0) |
5.5 (0.5 to 15) |
13.0 (10.0 to 17.0) |
0.007 |
| Baseline lung compliance (mmHg*l) |
38.7 (1.6) |
41.9 (2.0) |
41.7 (6.7) |
53.8 (1.6) |
0.01 |
| Baseline PaO2/FiO2 (mmHg) |
464 (440 to 540) |
412 (376 to 416) |
454 (400 to 488) |
450 (374 to 476) |
0.355 |
| Work of breathing (J/l) | 1.2 (0.05) | 1.1 (0.03) | 1.1 (0.07) | 1.0 (0.05) | 0.148 |
Data presented as mean (standard error of the mean) or median (interquartile range). Pairwise comparisons derived from analysis of variance (ANOVA) for weight were as follows: Sham–Sham + HF, −9.2 kg (95% confidence interval (CI) = −17.2 to −1.2), P = 0.016; Sham–CPB, 0.6 kg 95% CI = −5.8 to 6.9), P = 1.0; Sham–CPB + HF, −15.9 kg (95% CI = −24.3 to −7.4), P <0.001; CPB–CPB + HF, −16.7 kg (95% CI = −25.1 to −7.7), P <0.001. Pairwise comparisons derived from ANOVA for metaraminol dose were as follows: Sham–Sham + HF, 0.27 mg (95% CI = −10.4 to 10.9), P = 0.959; Sham–CPB, −11.9 mg (95% CI = −20.9 to −2.9), P = 0.012; Sham–CPB + HF, −14.1 (95% CI = −23.9 to −4.3), P = 0.006; CPB–CPB + HF, 2.3 mg (95% CI = −12.3 to 7.7), P = 0.651. CPB, cardiopulmonary bypass; HF, high-fat diet; PaO2/FiO2, partial pressure of oxygen/fraction of inspired oxygen.