Table 2.
Population pharmacokinetic parameters
| Parameters | Estimate | RSE (%) |
|---|---|---|
| θCL (L⋅h-1⋅kg-1) |
2 |
17 |
| θBW (CL(BWi) = θCL × BWi3/4 ) |
0.75 (fixed) |
NA |
| θq0 (μg⋅h-1⋅kg-1) |
0.15 |
19 |
| θBW (q0(BWi) = θq0 × BWi3/4 ) |
0.75 (fixed) |
NA |
| V (L) for a 10 Kg individual |
0.8 |
NA |
| T½ (min), for a 10 Kg individual |
3 |
NA |
| ηCL (square root of ω2CL) |
1 |
14 |
| ηq0 (square root of ω2q0) |
1.1 |
13 |
| Residual variability (proportional) |
0.3 |
15 |
| Correlation (ηCL, ηq0) | 0.88 | 5 |
The volume of distribution of epinephrine was ascribed to the circulating volume, estimated as a function of bodyweight (see Materials and methods). CL, elimination clearance; q0, endogenous production rate; V, volume of distribution; CV, circulating volume; θCL, typical unit clearance; θq0,typical unit endogenous production rate; θBW, bodyweight influential parameter; T½, half-life.
RSE, relative standard error; η, between-subject variability (BSV); BW, bodyweight; NA, not applicable.