Table 3.
Hemodynamic and metabolic population parameters
| Hemodynamic population parameters | Estimate | RSE (%) |
|---|---|---|
| HR0 (b⋅min-1) |
133 |
3 |
| θage (HR0i = HR0 x agei-0.061) |
-0.061 |
18 |
| HRmax (b⋅min-1) |
180 |
3 |
| C50 HR (μg⋅L-1) |
5.71 |
37 |
| SV⋅SVR0 |
0.31 |
3 |
| θage (SV⋅SVR0i = SV⋅SVR0 x agei0.094 ) |
0.094 |
14 |
| SV⋅SVRmax, RACHS-1 = category 2 |
0.44 |
20 |
| SV.SVRmax, RACHS-1 = categories 3,4 |
0.26 |
20 |
| C50 SV⋅SVR (μg.L-1) |
18 |
59 |
| ηHR0 (square root of ω2HR 0) |
0.14 |
14 |
| ηC50 HR (square root of ω2C 50 HR) |
1.22 |
17 |
| ηSV.SVR0 (square root of ω2SV.SVR0) |
0.13 |
17 |
| ηSV.SVRmax (square root of ω2SV.SVRmax) |
0.23 |
42 |
| Residual variability (proportional) |
|
|
| HR |
0.08 |
4 |
| MAP |
0.16 |
4 |
|
Metabolic population parameters |
|
|
| GLY0 (mmol⋅L-1) |
5.46 |
5 |
| Gmax |
1.69 |
6 |
| RGLY (mmol⋅L-1.min-1) |
0.04 |
25 |
| C50GLY (μg⋅L-1) |
0.52 |
9 |
| LAC0 (mmol⋅L-1) |
1.23 |
7 |
| ηGLY0 (square root of ω2GLY 0) |
0.21 |
23 |
| ηGmax (square root of ω2Gmax) |
0.213 |
26 |
| ηRGly (square root of ω2RGLY) |
1 |
21 |
| ηLAC0 (square root of ω2LAC0) |
0.33 |
18 |
| Residual variability (constant additive) |
|
|
| GLY (mmol⋅L-1) |
2.23 |
5 |
| LAC (mmol⋅L-1) | 0.5 | 11 |
HR0, basal heart rate; HRmax, maximal HR; C50HR, Ep concentration producing 50% of HR max; SV⋅SVR, product of stoke volume by systemic vascular resistances; SV⋅SVR0, basal SV⋅SVR value; SV.SVRmax, maximal SV⋅SVR value; C50SV⋅SVR, Ep concentration producing 50% of SV⋅SVRmax; RACHS-1, risk adjustment for congenital heart surgery 1; GLY0, basal plasma glucose level; RGLY, glucose zero-order production rate; Gmax, relative maximal increase in RGLY; C50GLY, Ep concentration that produces 50% of the maximal response on plasma glucose level; LAC0, basal plasma lactate level; RSE, relative standard error; η, between-subject variability (BSV); θage, age influential parameter.