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. Author manuscript; available in PMC: 2014 Jun 13.
Published in final edited form as: Biochem Cell Biol. 2011 Aug 18;89(5):445–458. doi: 10.1139/o11-039

Fig. 2. Factors involved in cohesin recruitment to specific genomic regions.

Fig. 2

A. Binding of RNA polymerase II, Mediator, and sequence-specific transcription factors (TFs), such as ERα, correlates with cohesin binding. B. Pre-replication complex (pre-RC), including the MCM complex, and cohesin binding to replication origins. C. ATP-dependent chromatin remodeling complex hSNF2h binds to cohesin and recruits it to a type of Alu repeat sequence in human cells. D. CTCF-dependent recruitment of cohesin to the insulator/boundary elements containing CTCF consensus binding sites. Additional factors, such as p68/SRA and ATRX, may dictate their binding selectivity. E. CTCF-independent cohesin recruitment to heterochromatic repeat sequences carrying histone H3K9me3 and HP1. At the pericentromeric heterochromatin in S. pombe, HP1 recruits cohesin. At the D4Z4 subtelomeric repeat regions in human cells, cohesin and HP1γ are co-recruited.