Table 3.

Time-constant coefficient estimates of Model 2 (time-varying effect model of regressing cessation fatigue on craving, negative affect, gender, the interaction between gender and craving, and the interaction between gender and negative affect, adjusting for lapse and baseline dependence, for three treatment groups respectively)

Group	Covariate	Estimate (SD)	p-value
Placebo	Male	-0.78 (0.14)	<.0001
	Male*Crav	-0.69 (0.15)	<.0001
	Male*NA	0.54 (0.18)	0.0022
	Lapse	0.24 (0.24)	0.3234
	Baseline dependence	-0.60 (0.10)	<.0001
Monotherapy	Male	-0.48 (0.06)	<.0001
	Male*Crav	-0.50 (0.07)	<.0001
	Male*NA	0.40 (0.07)	<.0001
	Lapse	0.61 (0.11)	<.0001
	Baseline dependence	0.24 (0.03)	<.0001
Combined therapy	Male	-0.32 (0.06)	<.0001
	Male*Crav	-0.24 (0.07)	0.0006
	Male*NA	0.04 (0.09)	0.6570
	Lapse	-0.32 (0.13)	0.0154
	Baseline dependence	0.14 (0.03)	<.0001

This table contains only the coefficient estimates of the model parameters that are assumed to be time-constant, namely, β3, β4, β5, β6, and β7. The inference of the time-varying effects that are of primary interest (i.e., the intercepts, the effects of craving and the effects of negative affect) can be drawn from Fig. 3, Fig. 4 and Fig. 5.