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. 2014 Jun 13;9(6):e96863. doi: 10.1371/journal.pone.0096863

Figure 3. Proliferation and apoptosis frequencies.

Figure 3

A: Representative islets showing insulin (red) and Ki67 (green, indicated by arrows), insulin (red) and TUNEL (green, indicated by arrows) immunoreactivity from non-pregnant and pregnant C57BL/6, GLP-1RKO and GIPRKO mice are shown. B: Beta cell proliferation frequency, expressed as % of beta cells analysed. C: Beta cell apoptosis frequency, expressed as % of beta cells analysed. D: Ki67/TUNEL ratio. Values are mean ± SEM of 6 observations unless otherwise indicated. ΔΔΔp<0.001 compared to respective non-pregnant controls. **p<0.01, ***p<0.001 compared to non-pregnant or pregnant C57BL/6 mice.