Table 3.
Health-related quality of life in surviving patients with acute kidney injury and comparison with general population
| SF-36 dimensions | Pre-ICU, all patients | Pre-ICU, survivors (6 months) | ICU discharge | Hospital discharge | 3 months after ICU discharge | 6 months after ICU discharge |
General population (61- to 70-year-old age group) |
Differences between pre-ICU survivors (n = 73) and non-survivors (n = 80)a |
Differences between pre-ICU survivors and general populationb | Differences between pre-ICU (n = 73) and 6 months after ICU discharge (n = 73)c | Differences between 6 months after ICU discharge and general populationb | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number | 172 | 73 | 99 | 79 | 74 | 73 | P value | Effect sizes |
P value | Effect sizes |
Wilks's lambda |
Effect sizes | P value | Effect sizes |
|
| PCS | 40.6 ± 12.6 | 42.3 ± 12.7 | 26.3 ± 5.9 | 31.2 ± 7.6 | 35.9 ± 10.8 | 37.1 ± 11.3 | - | 0.158 | 0.39 | - | - | 0.001d | 0.46 | - | - |
| MCS | 47.9 ± 10.6 | 49.7 ± 9.9 | 46.3 ± 9.4 | 47.5 ± 9.8 | 50.8 ± 9.2 | 49.9 ± 9.1 | - | 0.051 | 0.27 | - | - | 0.924 | 0.02 | - | - |
| PF | 58.7 ± 33.9 | 62.5 ± 34.2 | 6.01 ± 12.8 | 25.5 ± 22.9 | 48.6 ± 31.4 | 51.5 ± 32.9 | 71.7 ± 25.6 | 0.450 | 0.28 | 0.025 | 0.36 | 0.014d | 0.32 | < 0.001d | 0.61 |
| RP | 46.1 ± 47.1 | 51.4 ± 48.9 | 13.1 ± 31.2 | 14.2 ± 33.2 | 26.7 ± 41.0 | 35.6 ± 42.1 | 67.3 ± 40.9 | 0.144 | 0.32 | 0.007 | 0.39 | 0.027d | 0.32 | < 0.001 d | 0.75 |
| BP | 78.0 ± 25.6 | 82.4 ± 25.2 | 79.0 ± 22.3 | 83.1 ± 21.3 | 82.6 ± 24.3 | 79.4 ± 24.7 | 70.5 ± 24.6 | 0.029d | 0.38 | < 0.001d | 0.48 | 0.485 | 0.12 | 0.003d | 0.36 |
| GH | 48.9 ± 29.3 | 54.0 ± 29.3 | 29.0 ± 18.3 | 36.4 ± 21.5 | 42.1 ± 22.7 | 41.2 ± 21.2 | 61.7 ± 20.2 | 0.094 | 0.37 | 0.028 | 0.36 | 0.001d | 0.44 | < 0.001d | 0.96 |
| VT | 52.9 ± 25.2 | 55.5 ± 27.5 | 31.4 ± 15.3 | 44.2 ± 18.3 | 54.7 ± 20.5 | 53.3 ± 22.3 | 67.7 ± 19.6 | 0.336 | 0.20 | < 0.001d | 0.52 | 0.993 | 0.07 | < 0.001d | 0.64 |
| SF | 72.0 ± 24.3 | 77.6 ± 23.7 | 49.2 ± 22.9 | 58.2 ± 23.4 | 68.7 ± 25.4 | 72.9 ± 24.6 | 82.0 ± 24.6 | 0.014d | 0.44 | 0.115 | 0.19 | 0.202 | 0.19 | 0.002d | 0.37 |
| RE | 70.3 ± 42.3 | 75.8 ± 40.6 | 67.7 ± 42.4 | 62.0 ± 47.1 | 80.6 ± 37.8 | 73.9 ± 42.0 | 81.1 ± 35.0 | 0.166 | 0.25 | 0.268 | 0.04 | 0.948 | 0.04 | 0.152 | 0.17 |
| MH | 66.4 ± 17.3 | 69.7 ± 16.1 | 56.0 ± 11.2 | 62.3 ± 13.3 | 67.4 ± 14.0 | 67.3 ± 13.2 | 76.9 ± 17.9 | 0.021d | 0.40 | < 0.001d | 0.55 | 0.246 | 0.15 | < 0.001d | 0.54 |
Effect sizes of at least 0.20, at least 0.50, and greater than 0.80 correspond to small, medium, and large, respectively. Values are presented as mean ± standard deviation (SD). aUnivariate analysis of variance with Bonferroni correction P < 0.05 significant. bOne-sample t test. cGeneral linear model repeated measures with Bonferroni correction P < 0.05 significant. dP value significant after Bonferroni correction (P 0.05/10 = P = 0.005 = significant). SF-36 (Medical Outcomes Study 36-item Short-Form) dimension scores range from 0 to 100. Physical component score (PCS) and mental component score (MCS) are converted to mean 50 (SD 10). BP, bodily pain; GH, general health; MH, mental health; PF, physical functioning; RE, role limitation due to emotional problems; RP, role limitation due to physical problems; SF, social functioning; VT, vitality.