Table 2. SNPs within 50Table 1 that are associated (overall P-value <1E-03) with bronchodilator response (BDR) or inhaled corticosteroid (ICS) resistance in human clinical trial cohorts.
CHR | SNP | BP | A1 | A2 | A1 FREQ | P-value | Gene | Phenotype |
5 | rs13155012 | 150546065 | G | A | 0.93, 0.94, 0.94 | 7.6E-04 | CCDC69 | BDR |
16 | rs58151657 | 84867507 | G | A | 0.85, 0.88, 0.88 | 1.6E-04 | CRISPLD2 | BDR |
16 | rs8047416 | 84871409 | C | T | 0.88, 0.88, 0.88 | 4.4E-04 | CRISPLD2 | BDR |
16 | rs7189551 | 84958011 | T | C | 0.76, 0.76, 0.72, 0.78 | 7.8E-04 | CRISPLD2 | ICS Resistance |
16 | rs7188498 | 84958018 | G | A | 0.76, 0.75, 0.71, 0.78 | 5.1E-04 | CRISPLD2 | ICS Resistance |
16 | rs9928433 | 84958414 | A | G | 0.78, 0.80, 0.78, 0.84 | 5.8E-04 | CRISPLD2 | ICS Resistance |
16 | rs67343076 | 84964590 | G | A | 0.76, 0.78, 0.77, 0.83 | 3.3E-04 | CRISPLD2 | ICS Resistance |
16 | rs8061778 | 84986714 | G | T | 0.86, 0.84, 0.84, 0.79 | 7.5E-04 | CRISPLD2 | ICS Resistance |
A1 FREQ lists frequencies from individual cohorts used to compute overall P-value for each phenotype.