Table 2. SNPs within 50Table 1 that are associated (overall P-value <1E-03) with bronchodilator response (BDR) or inhaled corticosteroid (ICS) resistance in human clinical trial cohorts.

CHR	SNP	BP	A1	A2	A1 FREQ	P-value	Gene	Phenotype
5	rs13155012	150546065	G	A	0.93, 0.94, 0.94	7.6E-04	CCDC69	BDR
16	rs58151657	84867507	G	A	0.85, 0.88, 0.88	1.6E-04	CRISPLD2	BDR
16	rs8047416	84871409	C	T	0.88, 0.88, 0.88	4.4E-04	CRISPLD2	BDR
16	rs7189551	84958011	T	C	0.76, 0.76, 0.72, 0.78	7.8E-04	CRISPLD2	ICS Resistance
16	rs7188498	84958018	G	A	0.76, 0.75, 0.71, 0.78	5.1E-04	CRISPLD2	ICS Resistance
16	rs9928433	84958414	A	G	0.78, 0.80, 0.78, 0.84	5.8E-04	CRISPLD2	ICS Resistance
16	rs67343076	84964590	G	A	0.76, 0.78, 0.77, 0.83	3.3E-04	CRISPLD2	ICS Resistance
16	rs8061778	84986714	G	T	0.86, 0.84, 0.84, 0.79	7.5E-04	CRISPLD2	ICS Resistance

A1 FREQ lists frequencies from individual cohorts used to compute overall P-value for each phenotype.