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. 2014 Jun 13;9(6):e98867. doi: 10.1371/journal.pone.0098867

Table 1. IC50 values and combinatory index for treatment of p53-proficient and p53-deficient SCCHN cell lines with ATO and IR.

Cell line p53 genotype Class of mutation p21 fold induction* IC50 [μM ATO] CI at ED75 (IR+ATO) Effect
UT-SCC-9 Δ exon 2-9 disruptive 1.0 0.21 1.08 additive
UD-SCC-4 c.449 del13 frameshift 1.0 2.41 0.86 additive
SCC9 c.820 del32 frameshift 1.1 0.09 1.29 antagonism
UD-SCC-5 H179Y missense 1.0 0.45 0.95 additive
UM-SCC-11B C242S missense 1.0 0.31 0.98 additive
FaDu R248L missense 0.9 0.36 1.04 additive
UM-SCC-25 wt 0.7 0.03 0.69 synergism
UD-SCC-2 wt 2.1 3.3 0.90 additive
UM-SCC-17B wt 2.0 4.5 1.00 additive
UM-SCC-74B wt 15.0 31.9 0.93 additive

*IR-induced p21 induction as a measure of p53 function was determined 4 hs after irradiation of cells with 6 Gy.