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. 2014 Jan 26;16(7):924–932. doi: 10.1093/neuonc/not302

Fig. 3.

Fig. 3.

Multiplex ligation-dependent probe amplification (MLPA) analysis and Kaplan–Meier analysis according to MYCN status in 25 patients with supratentorial CNS-PNETs. (A) Intensity plot shows the results of MLPA (SALSA MLPA p302 and p303) analysis, which further revealed the frequent occurrence of chromosomal gains and losses (gains depicted in orange, losses in blue, amplifications/high-copy gains in red and unchanged region in white; on the x-axis, patients number; on the y-axis, chromosomal regions. (B) Representative elecropherograms of MLPA analysis of a tumor showing MYCN) amplification (SALSA MLPA p302-A1, MYCN probe 033327-L02466, length 436 bp. Normal cerebellar tissue was used as control). (C) In regard to event-free survival, the Kaplan–Meier analysis showed a clear trend to shorter survival, but significance was not reached (P= .062). (D) On the other hand, the Kaplan–Meier analysis revealed that patients with tumors harboring MYCN amplification showed shorter overall survival (P = .001).