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. 2014 Jan 26;16(7):975–983. doi: 10.1093/neuonc/not309

Table 4.

Results of multivariate analysis of survival of children with CNS tumors by ICCC-3 diagnostic groups (French National Registry of Childhood Solid Tumors, 2000–2008)

Diagnostic Groups According to the ICCC-33
III- CNS IIIa-Ependymomas and choroid plexus tumors IIIb-Astrocytomas IIIc-Embryonal tumors IIId-Other gliomas IIIe- Other specified tumors Xa-Germ cell tumors
HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
Sex
 Boys Ref Ref Ref Ref Ref Ref Ref
 Girls 1.1 (1.0–1.3) 1.1 (0.8–1.6) 1.0 (0.8–1.4) 1.1 (0.8–1.3) 0.9 (0.8–1.2) 1.7 (0.9–3.3) 0.8 (0.3–2.0)
Age
 <1 year 1.3 (1.1–1.7) 0.9 (0.5–1.6) 2.3 (1.3–4.0) 1.4 (0.9–1.9) 0.4 (0.2–0.9) 3.6 (1.3–10.3) 1.5 (0.3–6.9)
 1–4 years Ref Ref Ref Ref Ref Ref Ref
 5–9 years 0.9 (0.7–1.0) 0.6 (0.4–1.1) 1.2 (0.8–1.8) 0.4 (0.3–0.6) 1.6 (1.2–2.1) 0.9 (0.4–2.0) 1.0 (0.2–4.3)
 10–14 years 0.7 (0.6–0.8) 0.5 (0.3–0.9) 1.2 (0.8–1.8) 0.3 (0.2–0.4) 1.3 (0.9–1.7) 0.6 (0.2–1.5) 0.9 (0.3–3.3)
Grade
 Low grade Ref Ref Ref Ref Ref
 High grade 7.0 (5.9–8.3) 2.5 (1.7–3.8) 23.2 (16.7–32.3) 4.2 (3.0–6.1) 16.5 (8.0–33.9)
 Unknown 5.9 (4.8–7.3) 0.6 (0.1–4.2) 0.7 (0.3–1.5) 2.9 (2.0–4.1) 1.1 (0.1–8.6)
Site
 Supratentorial Ref Ref Ref Ref Ref Ref Ref
 Infratentorial 0.9 (0.8–1.1) 1.6 (1.0–2.4) 1.3 (0.9–1.8) 0.4 (0.3–0.6) 2.3 (1.7–3.0) 5.5 (1.8–16.7) 1.9 (0.3–10.4)
 Unspecified 0.5 (0.4–0.6) 0.9 (0.6–1.6) 0.8 (0.5–1.2) 1.0 (0.7–1.5) 1.6 (1.1–2.3) 1.2 (0.6–2.7) 1.1 (0.3–4.1)
Stage
 Not metastatic Ref Ref Ref Ref Ref Ref Ref
 Metastatic 1.3 (1.1–1.5) 2.2 (1.1–4.2) 5.9 (3.2–10.7) 1.5 (1.2–1.9) 0.7 (0.3–2.0) 1.2 (0.4–4.0) 1.8 (0.2–14.5)
Period
 2000–2002 Ref Ref Ref Ref Ref Ref Ref
 2003–2005 0.8 (0.7–0.9) 0.7 (0.4–1.0) 0.6 (0.4–0.9) 0.8 (0.6–1.1) 0.9 (0.7–1.2) 1.2 (0.5–2.5) 0.8 (0.3–2.3)
 2006–2008 0.7 (0.6–0.9) 0.3 (0.2–0.6) 0.7 (0.5–1.1) 0.7 (0.6–0.9) 0.9 (0.7–1.2) 1.0 (0.5–2.4) 0.3 (0.1–1.3)

Abbreviations: c-PNET: central primitive neuroectodermal tumors; NOS: not otherwise specified; ICCC-3: third version of the International Classification of Childhood Cancer.

Cox proportional hazards regression.

Low grade: Astrocytic tumors: M94003, M94203, M94113, M94503, M94211, M94103, M93841; Choroid plexus tumors: M93900; Ependymal tumors: M93913, M93941, M93933, M93831; Glial tumors of uncertain origin: M94441; Meningiomas: M95340, M95391, M95381, M95320, M95300, M95310, M95330, M95370; Mixed tumors: M93823; Neuronal and neuronal-glial tumors: M95061, M95061, M94121, M94130, M94930, M94920, M95051, M86801; Pineal parenchymal tumors: M93611; Tumors of the sellar region: M93501, M93511, M93521, M95820.

High grade: Astrocytic tumors: M94013, M94413, M94403, M94423, M94513;Choroid plexus tumors: M93903;Embryonal tumors: M95083, M94713, M94743, M94703, M94703, M95013, M94723, M94733, M94733; Ependymal tumors: M93923; Glial tumors of uncertain origin: M93813; Meningiomas: M95303, M95383; Mixed tumors: M93823; Neuronal and neuronal-glial tumors: M95053; Pineal parenchymal tumors: M93623, M93623.