Table 4.
Results of multivariate analysis of survival of children with CNS tumors by ICCC-3 diagnostic groups (French National Registry of Childhood Solid Tumors, 2000–2008)
| Diagnostic Groups According to the ICCC-33 |
|||||||
|---|---|---|---|---|---|---|---|
| III- CNS | IIIa-Ependymomas and choroid plexus tumors | IIIb-Astrocytomas | IIIc-Embryonal tumors | IIId-Other gliomas | IIIe- Other specified tumors | Xa-Germ cell tumors | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Sex | |||||||
| Boys | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Girls | 1.1 (1.0–1.3) | 1.1 (0.8–1.6) | 1.0 (0.8–1.4) | 1.1 (0.8–1.3) | 0.9 (0.8–1.2) | 1.7 (0.9–3.3) | 0.8 (0.3–2.0) |
| Age | |||||||
| <1 year | 1.3 (1.1–1.7) | 0.9 (0.5–1.6) | 2.3 (1.3–4.0) | 1.4 (0.9–1.9) | 0.4 (0.2–0.9) | 3.6 (1.3–10.3) | 1.5 (0.3–6.9) |
| 1–4 years | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| 5–9 years | 0.9 (0.7–1.0) | 0.6 (0.4–1.1) | 1.2 (0.8–1.8) | 0.4 (0.3–0.6) | 1.6 (1.2–2.1) | 0.9 (0.4–2.0) | 1.0 (0.2–4.3) |
| 10–14 years | 0.7 (0.6–0.8) | 0.5 (0.3–0.9) | 1.2 (0.8–1.8) | 0.3 (0.2–0.4) | 1.3 (0.9–1.7) | 0.6 (0.2–1.5) | 0.9 (0.3–3.3) |
| Grade | |||||||
| Low grade | Ref | Ref | Ref | – | Ref | Ref | – |
| High grade | 7.0 (5.9–8.3) | 2.5 (1.7–3.8) | 23.2 (16.7–32.3) | – | 4.2 (3.0–6.1) | 16.5 (8.0–33.9) | – |
| Unknown | 5.9 (4.8–7.3) | 0.6 (0.1–4.2) | 0.7 (0.3–1.5) | – | 2.9 (2.0–4.1) | 1.1 (0.1–8.6) | – |
| Site | |||||||
| Supratentorial | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Infratentorial | 0.9 (0.8–1.1) | 1.6 (1.0–2.4) | 1.3 (0.9–1.8) | 0.4 (0.3–0.6) | 2.3 (1.7–3.0) | 5.5 (1.8–16.7) | 1.9 (0.3–10.4) |
| Unspecified | 0.5 (0.4–0.6) | 0.9 (0.6–1.6) | 0.8 (0.5–1.2) | 1.0 (0.7–1.5) | 1.6 (1.1–2.3) | 1.2 (0.6–2.7) | 1.1 (0.3–4.1) |
| Stage | |||||||
| Not metastatic | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Metastatic | 1.3 (1.1–1.5) | 2.2 (1.1–4.2) | 5.9 (3.2–10.7) | 1.5 (1.2–1.9) | 0.7 (0.3–2.0) | 1.2 (0.4–4.0) | 1.8 (0.2–14.5) |
| Period | |||||||
| 2000–2002 | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| 2003–2005 | 0.8 (0.7–0.9) | 0.7 (0.4–1.0) | 0.6 (0.4–0.9) | 0.8 (0.6–1.1) | 0.9 (0.7–1.2) | 1.2 (0.5–2.5) | 0.8 (0.3–2.3) |
| 2006–2008 | 0.7 (0.6–0.9) | 0.3 (0.2–0.6) | 0.7 (0.5–1.1) | 0.7 (0.6–0.9) | 0.9 (0.7–1.2) | 1.0 (0.5–2.4) | 0.3 (0.1–1.3) |
Abbreviations: c-PNET: central primitive neuroectodermal tumors; NOS: not otherwise specified; ICCC-3: third version of the International Classification of Childhood Cancer.
Cox proportional hazards regression.
Low grade: Astrocytic tumors: M94003, M94203, M94113, M94503, M94211, M94103, M93841; Choroid plexus tumors: M93900; Ependymal tumors: M93913, M93941, M93933, M93831; Glial tumors of uncertain origin: M94441; Meningiomas: M95340, M95391, M95381, M95320, M95300, M95310, M95330, M95370; Mixed tumors: M93823; Neuronal and neuronal-glial tumors: M95061, M95061, M94121, M94130, M94930, M94920, M95051, M86801; Pineal parenchymal tumors: M93611; Tumors of the sellar region: M93501, M93511, M93521, M95820.
High grade: Astrocytic tumors: M94013, M94413, M94403, M94423, M94513;Choroid plexus tumors: M93903;Embryonal tumors: M95083, M94713, M94743, M94703, M94703, M95013, M94723, M94733, M94733; Ependymal tumors: M93923; Glial tumors of uncertain origin: M93813; Meningiomas: M95303, M95383; Mixed tumors: M93823; Neuronal and neuronal-glial tumors: M95053; Pineal parenchymal tumors: M93623, M93623.